Metabolic footprint of Lactobacillus acidophilus NCFM at different pH

Karolina Sulek, Henrik Lauritz Frandsen, Jørn Smedsgaard, Thomas Hjort Skov, Andrea Wilcks, Tine Rask Licht

Research output: Contribution to journalJournal articleResearchpeer-review


Lactobacillus acidophilus NCFM is a well known microorganism from the genomic and probiotic point of view. In order to analyze the potential interactions of NCFM with the surrounding environment, in vitro tests with the metabolic footprinting approach were performed. It was found that NCFM increased the concentration of lactic acid, succinic acid, adenine and arginine in the medium. The metabolism of NCFM did not change significantly between pH 5 and 7, suggesting that other environmental factors than pH might have bigger impact on its colonization throughout the gastrointestinal tract.
Original languageEnglish
Issue number2
Pages (from-to)244-252
Publication statusPublished - 2012


  • Probiotics
  • LCMS
  • Lactobacillus acidophilus NCFM
  • Metabolite footprint
  • GIT
  • Metabolomics


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