Metabolic engineering with systems biology tools to optimize production of prokaryotic secondary metabolites

Hyun Uk Kim; Pep Charusanti; Sang Yup Lee; Tilmann Weber

doi:10.1039/C6NP00019C

Metabolic engineering with systems biology tools to optimize production of prokaryotic secondary metabolites

Hyun Uk Kim, Pep Charusanti, Sang Yup Lee, Tilmann Weber

Novo Nordisk Foundation Center for Biosustainability

Korea Advanced Institute of Science and Technology

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Abstract

Metabolic engineering using systems biology tools is increasingly applied to overproduce secondary metabolites for their potential industrial production. In this Highlight, recent relevant metabolic engineering studies are analyzed with emphasis on host selection and engineering approaches for the optimal production of various prokaryotic secondary metabolites: native versus heterologous hosts (e.g., Escherichia coli) and rational versus random approaches. This comparative analysis is followed by discussions on systems biology tools deployed in optimizing the production of secondary metabolites. The potential contributions of additional systems biology tools are also discussed in the context of current challenges encountered during optimization of secondary metabolite production.

Original language	English
Journal	Natural Product Reports
Volume	33
Pages (from-to)	933-941
Number of pages	9
ISSN	0265-0568
DOIs	https://doi.org/10.1039/C6NP00019C
Publication status	Published - 2016

Bibliographical note

This article is published Open Access as part of the RSC's Gold for Gold initiative, licensed under a Creative Commons Attribution 3.0 Unported Licence.

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10.1039/C6NP00019C

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The next generation of 'omics-based natural products discovery
Weber, T. (Invited speaker)
20 Jan 2017
Activity: Talks and presentations › Conference presentations

Cite this

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Metabolic engineering with systems biology tools to optimize production of prokaryotic secondary metabolites

Abstract

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The next generation of 'omics-based natural products discovery

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