Metabolic engineering for increased lipid accumulation in Yarrowia lipolytica – A Review

Jinpeng Wang, Rodrigo Ledesma-Amaro, Yongjun Wei, Boyang Ji, Xiao Jun Ji*

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review


Current energy security and climate change policies encourage the development and utilization of bioenergy. Oleaginous yeasts provide a particularly attractive platform for the sustainable production of biofuels and industrial chemicals due to their ability to accumulate high amounts of lipids. In particular, microbial lipids in the form of triacylglycerides (TAGs) produced from renewable feedstocks have attracted considerable attention because they can be directly used in the production of biodiesel and oleochemicals analogous to petrochemicals. As an oleaginous yeast that is generally regarded as safe, Yarrowia lipolytica has been extensively studied, with large amounts of data on its lipid metabolism, genetic tools, and genome sequencing and annotation. In this review, we highlight the newest strategies for increasing lipid accumulation using metabolic engineering and summarize the research advances on the overaccumulation of lipids in Y. lipolytica. Finally, perspectives for future engineering approaches are proposed.
Original languageEnglish
Article number123707
JournalBioresource Technology
Number of pages11
Publication statusPublished - 2020


  • Yarrowia lipolytica
  • Metabolic engineering
  • Lipid accumulation
  • Triacylglycerides
  • Biodiesel

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