Melatonin Does Not Affect Oxidative/Inflammatory Biomarkers in a Closed-Chest Porcine Model of Acute Myocardial Infarction

Natalie L. Halladin, Sarah Ekelof, Svend Eggert Jensen, Jens Aaroe, Benedict Kjaergaard, Peter M. H. Heegaard, Jens Lykkesfeldt, Jacob Rosenberg, Ismail Gogenur

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    Abstract

    Aim: To test whether melatonin reduces oxidative and inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction. Materials and Methods: Twenty pigs were randomized to receive a total dosage of 200 mg (0.4 mg/ml) of melatonin, or placebo immediately prior to reperfusion of a coronary artery balloon occlusion in a randomized, observer-blinded, placebo-controlled trial. We assessed high-sensitivity troponin T (hs-TnT), malondialdehyde and interleukin-1b, -6 and -10 at baseline, 30 min and 1, 2, 3 and 4 h after the start of reperfusion. Results: Seventeen pigs completed the trial. There was an increase in hs-TnT, but no significant difference between the melatonin-treated and placebo-treated groups. There were no significant differences in development of any of the circulating plasma markers between the two groups. Conclusion: Melatonin treatment did not result in reduction of inflammatory or oxidative stress markers after experimental myocardial infarction compared to placebo.
    Original languageEnglish
    JournalIn Vivo
    Volume28
    Issue number4
    Pages (from-to)483-488
    Number of pages6
    ISSN0258-851X
    Publication statusPublished - 2014

    Keywords

    • Melatonin
    • closed-chest porcine model
    • acute myocardial infarction
    • cytokines

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