Mechanistic modeling of industrial fermentation processes for antibiotic production

Atli Freyr Magnusson; Stuart M. Stocks; Jari P. Pajander; Gürkan Sin

doi:10.1016/B978-0-443-15274-0.50195-5

Mechanistic modeling of industrial fermentation processes for antibiotic production

Atli Freyr Magnusson^*, Stuart M. Stocks, Jari P. Pajander, Gürkan Sin

^*Corresponding author for this work

LEO Pharma AS

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Abstract

An unstructured mechanistic model is proposed to describe the industrial-scale production of Fusidic Acid in fed-batch cultivations. The model accounts for differences in dead and viable biomass and the effect of the primary carbon source and oxygen on cell growth and production. The model parameter is calibrated, and performance is tested using experimental data obtained from an operating industrial production in Denmark. The model predicted the main product concentration with a relative mean error of 7%. These successful implementations open up opportunities for soft sensor implementations for key state variables but also set a good foundation for further model extensions, such as hybrid modeling.

Original language	English
Title of host publication	Proceedings of the 33rd European Symposium on Computer Aided Process Engineering
Editors	Antonis Kokossis, Michael C. Georgiadis, Efstratios N. Pistikopoulos
Publisher	Elsevier
Publication date	2023
Pages	1223-1228
ISBN (Print)	978-0-443-23553-5, 978-0-443-15274-0
DOIs	https://doi.org/10.1016/B978-0-443-15274-0.50195-5
Publication status	Published - 2023
Event	33rd European Symposium on Computer Aided Process Engineering - Athens, Greece Duration: 18 Jun 2023 → 21 Jun 2023

Conference

Conference	33rd European Symposium on Computer Aided Process Engineering
Country/Territory	Greece
City	Athens
Period	18/06/2023 → 21/06/2023

Series	Computer Aided Chemical Engineering
Volume	52
ISSN	1570-7946

Keywords

Fermentation
Process Modelling
Pharmaceuticals

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Magnusson, A. F., Stocks, S. M., P. Pajander, J., & Sin, G. (2023). Mechanistic modeling of industrial fermentation processes for antibiotic production. In A. Kokossis, M. C. Georgiadis, & E. N. Pistikopoulos (Eds.), Proceedings of the 33rd European Symposium on Computer Aided Process Engineering (pp. 1223-1228). Elsevier. https://doi.org/10.1016/B978-0-443-15274-0.50195-5

Magnusson, Atli Freyr ; Stocks, Stuart M. ; P. Pajander, Jari et al. / Mechanistic modeling of industrial fermentation processes for antibiotic production. Proceedings of the 33rd European Symposium on Computer Aided Process Engineering. editor / Antonis Kokossis ; Michael C. Georgiadis ; Efstratios N. Pistikopoulos. Elsevier, 2023. pp. 1223-1228 (Computer Aided Chemical Engineering, Vol. 52).

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abstract = "An unstructured mechanistic model is proposed to describe the industrial-scale production of Fusidic Acid in fed-batch cultivations. The model accounts for differences in dead and viable biomass and the effect of the primary carbon source and oxygen on cell growth and production. The model parameter is calibrated, and performance is tested using experimental data obtained from an operating industrial production in Denmark. The model predicted the main product concentration with a relative mean error of 7%. These successful implementations open up opportunities for soft sensor implementations for key state variables but also set a good foundation for further model extensions, such as hybrid modeling.",

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author = "Magnusson, {Atli Freyr} and Stocks, {Stuart M.} and {P. Pajander}, Jari and G{\"u}rkan Sin",

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booktitle = "Proceedings of the 33rd European Symposium on Computer Aided Process Engineering",

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note = "33rd European Symposium on Computer Aided Process Engineering, ESCAPE33 ; Conference date: 18-06-2023 Through 21-06-2023",

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Magnusson, AF, Stocks, SM, P. Pajander, J & Sin, G 2023, Mechanistic modeling of industrial fermentation processes for antibiotic production. in A Kokossis, M C. Georgiadis & E N. Pistikopoulos (eds), Proceedings of the 33rd European Symposium on Computer Aided Process Engineering. Elsevier, Computer Aided Chemical Engineering, vol. 52, pp. 1223-1228, 33rd European Symposium on Computer Aided Process Engineering, Athens, Greece, 18/06/2023. https://doi.org/10.1016/B978-0-443-15274-0.50195-5

Mechanistic modeling of industrial fermentation processes for antibiotic production. / Magnusson, Atli Freyr; Stocks, Stuart M.; P. Pajander, Jari et al.
Proceedings of the 33rd European Symposium on Computer Aided Process Engineering. ed. / Antonis Kokossis; Michael C. Georgiadis; Efstratios N. Pistikopoulos. Elsevier, 2023. p. 1223-1228 (Computer Aided Chemical Engineering, Vol. 52).

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

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AU - Sin, Gürkan

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KW - Process Modelling

KW - Pharmaceuticals

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SN - 978-0-443-15274-0

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Magnusson AF, Stocks SM, P. Pajander J, Sin G. Mechanistic modeling of industrial fermentation processes for antibiotic production. In Kokossis A, C. Georgiadis M, N. Pistikopoulos E, editors, Proceedings of the 33rd European Symposium on Computer Aided Process Engineering. Elsevier. 2023. p. 1223-1228. (Computer Aided Chemical Engineering, Vol. 52). doi: 10.1016/B978-0-443-15274-0.50195-5

Mechanistic modeling of industrial fermentation processes for antibiotic production

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