Mechanistic investigation of the gold-catalyzed aerobic oxidation of aldehydes: added insight from Hammett studies and isotopic labelling experiments

Peter Fristrup, Louise Bahn Johansen, Claus Hviid Christensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The gold-catalyzed aerobic oxidation of aldehydes proceeds through development of a partial negative charge and has a significant kinetic isotope effect (k(H)/k(D) = 2.8-2.9), which illustrates that activation of the C-H bond takes place in the rate-determining step.
Original languageEnglish
JournalChemical Communications
Issue number24
Pages (from-to)2750-2752
ISSN1359-7345
DOIs
Publication statusPublished - 2008

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