Mechanistic Investigation of Molybdate-Catalysed Transfer Hydrodeoxygenation

Daniel Bo Larsen, Allan Robertson Petersen, Johannes Rytter Dethlefsen, Ayele Teshome Gorfo, Peter Fristrup

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Abstract

The molybdate-catalysed transfer hydrodeoxygenation (HDO) of benzyl alcohol to toluene driven by oxidation of the solvent isopropyl alcohol to acetone has been investigated by using a combination of experimental and computational methods. A Hammett study that compared the relative rates for the transfer HDO of five para-substituted benzylic alcohols was carried out. Density-functional theory (DFT) calculations suggest a transition state with significant loss of aromaticity contributes to the lack of linearity observed in the Hammett study. The transfer HDO could also be carried out in neat PhCH2OH at 175°C. Under these conditions, PhCH2OH underwent disproportionation to yield benzaldehyde, toluene, and significant amounts of bibenzyl. Isotopic-labelling experiments (using PhCH2OD and PhCD2OH) showed that incorporation of deuterium into the resultant toluene originated from the αposition of benzyl alcohol, which is in line with the mechanism suggested by the DFT study.
Original languageEnglish
JournalChemistry: A European Journal
Volume22
Issue number46
Pages (from-to)16621-16631
Number of pages11
ISSN0947-6539
DOIs
Publication statusPublished - 2016

Keywords

  • Hammett
  • Density functional calculations
  • Deoxygenation
  • Homogeneous catalysis
  • Molybdenum

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