Abstract
Glucose isomerisation to fructose can occur by different pathways and the mechanism of zeolite-catalysed glucose isomerisation in methanol has remained incompletely understood. Herein, the mechanism is studied using an 1H-13C HSQC NMR assay resolving different fructose isotopomers. We find that zeolite-catalysed glucose isomerisation proceeds predominantly via a hydride shift into the pro-R position of fructose, thus resembling the stereoselectivity of the enzymatic isomerisation process.
Original language | English |
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Journal | Chemical Communications |
Volume | 52 |
Pages (from-to) | 12773-12776 |
Number of pages | 4 |
ISSN | 1359-7345 |
DOIs | |
Publication status | Published - 2016 |