Measuring density and compressibility of white blood cells and prostate cancer cells by microchannel acoustophoresis

Rune Barnkob, Per Augustsson, Cecilia Magnusson, Hans Lilja, Thomas Laurell, Henrik Bruus

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

    Abstract

    We present a novel method for the determination of density and compressibility of individual particles and cells undergoing microchannel acoustophoresis in an arbitrary 2D acoustic field. Our method is a critical advancement within acoustophoretic separation of biological cells, as the ability to determine the density and compressibility of individual cells enables the prediction and alteration of the separation outcome for a given cell mixture. We apply the method on white blood cells (WBCs) and DU145 prostate cancer cells (DUCs) aiming to improve isolation of circulating tumor cells from blood, an emerging tool in the monitoring and characterizing of metastatic cancer.
    Original languageEnglish
    Title of host publicationProceedings of the 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    Publication date2011
    Pages127-129
    ISBN (Print)978-0-9798064-4-5
    Publication statusPublished - 2011
    Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Seattle, United States
    Duration: 2 Oct 20116 Oct 2011
    Conference number: 15
    https://microtasconferences.org/microtas2011/

    Conference

    Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    Number15
    Country/TerritoryUnited States
    CitySeattle
    Period02/10/201106/10/2011
    Internet address

    Keywords

    • Ultrasound Resonances
    • Micro-PIV
    • Acoustophoresis
    • Cell Handling

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