Mean first passage time analysis reveals rate-limiting steps, parallel pathways and dead ends in a simple model of protein folding

Mille Micheelsen, Christian Rischel, Jesper Ferkinghoff-Borg, Raphael Guerois, Luis Serrano

Research output: Contribution to journalJournal articleResearchpeer-review


We have analyzed dynamics on the complex free-energy landscape of protein folding in the FOLD-X model, by calculating for each state of the system the mean first-passage time to the folded state. The resulting kinetic map of the folding process shows that it proceeds in jumps between well-defined, local free-energy minima. Closer analysis of the different local minima allows us to reveal secondary, parallel pathways as well as dead ends
Original languageEnglish
Issue number4
Pages (from-to)561-566
Publication statusPublished - 2003
Externally publishedYes

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