Matrix Metalloproteinases: How Much Can They Do?

Magnus S. Ågren*, Ulrich auf dem Keller

*Corresponding author for this work

Research output: Contribution to journalEditorialpeer-review

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Abstract

Zinc-dependent matrix metalloproteinases (MMPs) belong to metzincins that comprise not only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a disintegrin and metalloproteinase domain) and 19 secreted ADAMTSs (a disintegrin and metalloproteinase thrombospondin domain). The many setbacks from the clinical trials of broad-spectrum MMP inhibitors for cancer indications in the late 1990s emphasized the extreme complexity of the participation of these proteolytic enzymes in biology. This editorial mini-review summarizes the Special Issue, which includes four review articles and 10 original articles that highlight the versatile roles of MMPs, ADAMs, and ADAMTSs, in normal physiology as well as in neoplastic and destructive processes in tissue. In addition, we briefly discuss the unambiguous involvement of MMPs in wound healing.
Original languageEnglish
Article number2678
JournalInternational Journal of Molecular Sciences
Volume21
Issue number8
Number of pages9
ISSN1661-6596
DOIs
Publication statusPublished - 2020

Keywords

  • Extracellular matrix
  • Inflammation
  • Wound healing
  • Cytokines
  • Proteinases
  • Interstitial collagens

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