Material properties in complement activation

S. Moein Moghimi, Alina Joukainen Andersen, Davoud Ahmadvand, Peter P. Wibroe, Thomas Lars Andresen, A. Christy Hunter

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Uncontrolled complement activation can induce many inflammatory and life threatening conditions. Accordingly, the role of complement in initiation of adverse reactions to polymers and nanoparticulate drug carriers is receiving increasing attention and has prompted extensive ‘structure-immune performance’ relationship studies in nanomedicine research at many fronts. The interaction between nanomaterials and the complement system is complex and regulated by inter-related factors that include nanoscale size, morphology and surface characteristics. Each of these parameters may affect complement activation differently and through different sensing molecules and initiation pathways. The importance of material properties in triggering complement is considered and mechanistic aspects discussed. Mechanistic understanding of complement events could provide rational approaches for improved material design and nanoengineering strategies for clinical medicine.
    Original languageEnglish
    JournalAdvanced Drug Delivery Reviews
    Volume63
    Issue number12
    Pages (from-to)1000-1007
    ISSN0169-409x
    DOIs
    Publication statusPublished - 2011

    Keywords

    • Nanomedicine
    • Nanospheres
    • Acute allergic reactions
    • Nanotoxicology
    • Polymers
    • Liposomes

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