Mapuche HerbalMedicine Inhibits Blood Platelet Aggregation

Susan Skanderup Falkenberg, Inge Tarnow, Alfonso Guzman, Henrik Toft Simonsen

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Abstract

12 plant species traditionally used by the Mapuche people in Chile to treat wounds and inflammations have been evaluated for their direct blood platelet inhibition. Seven of the 12 tested plant species showed platelet inhibitory effect in sheep blood, and four of these were also able to inhibit the ADP- (5.0 μM) and collagen- (2.0 μg/mL) induced aggregations in human blood. These four species in respective extracts (in brackets) were Blechnum chilense (MeOH), Luma apiculata (H2O), Amomyrtus luma (DCM:MeOH1 : 1) and Cestrumparqui (DCM:MeOH 1 : 1). The platelet aggregating inhibitory effects of A. luma (DCM:MeOH 1 : 1), and L. apiculata (H2O) were substantial and confirmed by inhibition of platelet surface activation markers.
Original languageEnglish
JournalEvidence-Based Complementary and Alternative Medicine
Pages (from-to)647620
ISSN1741-427X
DOIs
Publication statusPublished - 2012
Externally publishedYes

Cite this

Falkenberg, Susan Skanderup ; Tarnow, Inge ; Guzman, Alfonso ; Simonsen, Henrik Toft. / Mapuche HerbalMedicine Inhibits Blood Platelet Aggregation. In: Evidence-Based Complementary and Alternative Medicine. 2012 ; pp. 647620.
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Mapuche HerbalMedicine Inhibits Blood Platelet Aggregation. / Falkenberg, Susan Skanderup; Tarnow, Inge; Guzman, Alfonso; Simonsen, Henrik Toft.

In: Evidence-Based Complementary and Alternative Medicine, 2012, p. 647620.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Mapuche HerbalMedicine Inhibits Blood Platelet Aggregation

AU - Falkenberg, Susan Skanderup

AU - Tarnow, Inge

AU - Guzman, Alfonso

AU - Simonsen, Henrik Toft

PY - 2012

Y1 - 2012

N2 - 12 plant species traditionally used by the Mapuche people in Chile to treat wounds and inflammations have been evaluated for their direct blood platelet inhibition. Seven of the 12 tested plant species showed platelet inhibitory effect in sheep blood, and four of these were also able to inhibit the ADP- (5.0 μM) and collagen- (2.0 μg/mL) induced aggregations in human blood. These four species in respective extracts (in brackets) were Blechnum chilense (MeOH), Luma apiculata (H2O), Amomyrtus luma (DCM:MeOH1 : 1) and Cestrumparqui (DCM:MeOH 1 : 1). The platelet aggregating inhibitory effects of A. luma (DCM:MeOH 1 : 1), and L. apiculata (H2O) were substantial and confirmed by inhibition of platelet surface activation markers.

AB - 12 plant species traditionally used by the Mapuche people in Chile to treat wounds and inflammations have been evaluated for their direct blood platelet inhibition. Seven of the 12 tested plant species showed platelet inhibitory effect in sheep blood, and four of these were also able to inhibit the ADP- (5.0 μM) and collagen- (2.0 μg/mL) induced aggregations in human blood. These four species in respective extracts (in brackets) were Blechnum chilense (MeOH), Luma apiculata (H2O), Amomyrtus luma (DCM:MeOH1 : 1) and Cestrumparqui (DCM:MeOH 1 : 1). The platelet aggregating inhibitory effects of A. luma (DCM:MeOH 1 : 1), and L. apiculata (H2O) were substantial and confirmed by inhibition of platelet surface activation markers.

U2 - 10.1155/2012/647620

DO - 10.1155/2012/647620

M3 - Journal article

SP - 647620

JO - Evidence-Based Complementary and Alternative Medicine

JF - Evidence-Based Complementary and Alternative Medicine

SN - 1741-427X

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