Mapuche HerbalMedicine Inhibits Blood Platelet Aggregation

Susan Skanderup Falkenberg, Inge Tarnow, Alfonso Guzman, Henrik Toft Simonsen

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Abstract

12 plant species traditionally used by the Mapuche people in Chile to treat wounds and inflammations have been evaluated for their direct blood platelet inhibition. Seven of the 12 tested plant species showed platelet inhibitory effect in sheep blood, and four of these were also able to inhibit the ADP- (5.0 μM) and collagen- (2.0 μg/mL) induced aggregations in human blood. These four species in respective extracts (in brackets) were Blechnum chilense (MeOH), Luma apiculata (H2O), Amomyrtus luma (DCM:MeOH1 : 1) and Cestrumparqui (DCM:MeOH 1 : 1). The platelet aggregating inhibitory effects of A. luma (DCM:MeOH 1 : 1), and L. apiculata (H2O) were substantial and confirmed by inhibition of platelet surface activation markers.
Original languageEnglish
JournalEvidence-Based Complementary and Alternative Medicine
Pages (from-to)647620
ISSN1741-427X
DOIs
Publication statusPublished - 2012
Externally publishedYes

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