Making bubbles: Targeting VPS41 induces vacuolization and methuosis

Nienke Julia Dekker; Luca Laraia

doi:10.1016/j.chembiol.2023.01.008

Making bubbles: Targeting VPS41 induces vacuolization and methuosis

Nienke Julia Dekker, Luca Laraia^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Comment/debate › Research › peer-review

Abstract

In this issue of Cell Chemical Biology, Liu et al. describe the natural product DMBP as the first tool compound for VPS41. Treatment with DMBP induced vacuolization and methuosis and inhibited autophagic flux in lung and pancreatic cancer cell lines, validating VPS41 as a potential therapeutic target.

Original language	English
Journal	Cell Chemical Biology
Volume	30
Issue number	2
Pages (from-to)	127-129
ISSN	2451-9456
DOIs	https://doi.org/10.1016/j.chembiol.2023.01.008
Publication status	Published - 2023

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10.1016/j.chembiol.2023.01.008

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title = "Making bubbles: Targeting VPS41 induces vacuolization and methuosis",

abstract = "In this issue of Cell Chemical Biology, Liu et al. describe the natural product DMBP as the first tool compound for VPS41. Treatment with DMBP induced vacuolization and methuosis and inhibited autophagic flux in lung and pancreatic cancer cell lines, validating VPS41 as a potential therapeutic target.",

author = "Dekker, {Nienke Julia} and Luca Laraia",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

doi = "10.1016/j.chembiol.2023.01.008",

language = "English",

volume = "30",

pages = "127--129",

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TY - JOUR

T1 - Making bubbles

T2 - Targeting VPS41 induces vacuolization and methuosis

AU - Dekker, Nienke Julia

AU - Laraia, Luca

PY - 2023

Y1 - 2023

N2 - In this issue of Cell Chemical Biology, Liu et al. describe the natural product DMBP as the first tool compound for VPS41. Treatment with DMBP induced vacuolization and methuosis and inhibited autophagic flux in lung and pancreatic cancer cell lines, validating VPS41 as a potential therapeutic target.

AB - In this issue of Cell Chemical Biology, Liu et al. describe the natural product DMBP as the first tool compound for VPS41. Treatment with DMBP induced vacuolization and methuosis and inhibited autophagic flux in lung and pancreatic cancer cell lines, validating VPS41 as a potential therapeutic target.

U2 - 10.1016/j.chembiol.2023.01.008

DO - 10.1016/j.chembiol.2023.01.008

M3 - Comment/debate

C2 - 36800990

AN - SCOPUS:85147800724

SN - 2451-9456

VL - 30

SP - 127

EP - 129

JO - Cell Chemical Biology

JF - Cell Chemical Biology

IS - 2

ER -

Making bubbles: Targeting VPS41 induces vacuolization and methuosis

Abstract

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