Making bubbles: Targeting VPS41 induces vacuolization and methuosis

Nienke Julia Dekker, Luca Laraia*

*Corresponding author for this work

Research output: Contribution to journalComment/debateResearchpeer-review

Abstract

In this issue of Cell Chemical Biology, Liu et al. describe the natural product DMBP as the first tool compound for VPS41. Treatment with DMBP induced vacuolization and methuosis and inhibited autophagic flux in lung and pancreatic cancer cell lines, validating VPS41 as a potential therapeutic target.

Original languageEnglish
JournalCell Chemical Biology
Volume30
Issue number2
Pages (from-to)127-129
ISSN2451-9456
DOIs
Publication statusPublished - 2023

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