Making bubbles: Targeting VPS41 induces vacuolization and methuosis

Nienke Julia Dekker, Luca Laraia*

*Corresponding author for this work

Research output: Contribution to journalComment/debateResearchpeer-review


In this issue of Cell Chemical Biology, Liu et al. describe the natural product DMBP as the first tool compound for VPS41. Treatment with DMBP induced vacuolization and methuosis and inhibited autophagic flux in lung and pancreatic cancer cell lines, validating VPS41 as a potential therapeutic target.

Original languageEnglish
JournalCell Chemical Biology
Issue number2
Pages (from-to)127-129
Publication statusPublished - 2023


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