TY - JOUR
T1 - Magnetoresponsive liposomes applications in nanomedicine
T2 - A comprehensive review
AU - Shahsavari, Shayan
AU - Rad, Mohammad Behnam
AU - Hajiaghajani, Amirhossein
AU - Rostami, Mohammadreza
AU - Hakimian, Fatemeh
AU - Jafarzadeh, Sina
AU - Hasany, Masoud
AU - Collingwood, Joanna F.
AU - Aliakbari, Farhang
AU - Fouladiha, Hamideh
AU - Bardania, Hassan
AU - Otzen, Daniel E.
AU - Morshedi, Dina
N1 - Publisher Copyright:
© 2024
PY - 2024
Y1 - 2024
N2 - Safe and effective cancer therapy requires a suitable nanocarrier that can target particular sites, such as cancer cells, in a selective manner. With the tremendous growth in nanotechnology, liposomes, among various competing nanocarriers, have shown promising advances in cancer therapy. Magnetic nanoparticles and metal ions are wide-reaching candidates for conferring magnetic properties and for incorporation into liposomes. Combining liposomes with magnetic structures enables construction of magnetoresponsive liposomes, allowing stimuli-responsiveness to an alternating magnetic field, magnetic targeting, and tracking by magnetic resonance imaging, which could all occur in parallel. This review presents a comprehensive analysis of the practical advances and novel aspects of design, synthesis and engineering magnetoresponsive liposomes, emphasizing their diverse properties for various applications. Our work explores the innovative uses of these structures, extending beyond drug delivery to include smart contrast agents, cell labeling, biosensing, separation, and filtering. By comparing new findings with earlier studies, we showcase significant improvements in efficiency and uncover new potentials, setting a new benchmark for future research in the field of magnetoresponsive liposomes.
AB - Safe and effective cancer therapy requires a suitable nanocarrier that can target particular sites, such as cancer cells, in a selective manner. With the tremendous growth in nanotechnology, liposomes, among various competing nanocarriers, have shown promising advances in cancer therapy. Magnetic nanoparticles and metal ions are wide-reaching candidates for conferring magnetic properties and for incorporation into liposomes. Combining liposomes with magnetic structures enables construction of magnetoresponsive liposomes, allowing stimuli-responsiveness to an alternating magnetic field, magnetic targeting, and tracking by magnetic resonance imaging, which could all occur in parallel. This review presents a comprehensive analysis of the practical advances and novel aspects of design, synthesis and engineering magnetoresponsive liposomes, emphasizing their diverse properties for various applications. Our work explores the innovative uses of these structures, extending beyond drug delivery to include smart contrast agents, cell labeling, biosensing, separation, and filtering. By comparing new findings with earlier studies, we showcase significant improvements in efficiency and uncover new potentials, setting a new benchmark for future research in the field of magnetoresponsive liposomes.
KW - Lipid
KW - Magnetic nanoparticles
KW - Magnetoresponsive
KW - Metal chelates
KW - MRI
KW - Theranostics
U2 - 10.1016/j.biopha.2024.117665
DO - 10.1016/j.biopha.2024.117665
M3 - Review
C2 - 39541790
AN - SCOPUS:85208759752
SN - 0753-3322
VL - 181
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
M1 - 117665
ER -