Magnetically Actuated Wormlike Nanomotors for Controlled Cargo Release

Min Liu, Liqing Pan, Hongguang Piao, Hongyu Sun, Xiufeng Huang, Changde Peng, Yiman Liu

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Magnetically actuated nanomotor, which swims under externally applied magnetic fields, shows great promise for controlled cargo delivery and release in biological fluids. Here, we report an on-demand release of 6-carboxyfluoresceins (FAM), a green fluorescein, from G-quadruplex DNA functionalized magnetically actuated wormlike nanomotors by applying an alternating magnetic field. This field-triggered FAM releasing process can be easily controlled by multiple parameters such as magnetic field, frequency, and exposure time. In addition, the experimental results and the theoretical simulation demonstrate that both a thermal and a nonthermal mechanism are involved in the cargo releasing process.
Original languageEnglish
JournalA C S Applied Materials and Interfaces
Volume7
Issue number47
Pages (from-to)26017-26021
Number of pages5
ISSN1944-8244
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • CoFe2O4 nanoparticles
  • HeLa cells
  • Cargo delivery
  • Magnetic actuation
  • Wormlike nanomotor

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