Magnetic resonance temporal diffusion tensor spectroscopy of disordered anisotropic tissue

Jonathan Scharff Nielsen, Tim Bjørn Dyrby, Henrik Lundell*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

297 Downloads (Pure)


Molecular diffusion measured with diffusion weighted MRI (DWI) offers a probe for tissue microstructure. However, inferring microstructural properties from conventional DWI data is a complex inverse problem and has to account for heterogeneity in sizes, shapes and orientations of the tissue compartments contained within an imaging voxel. Alternative experimental means for disentangling the signal signatures of such features could provide a stronger link between the data and its interpretation. Double diffusion encoding (DDE) offers the possibility to factor out variation in compartment shapes from orientational dispersion of anisotropic domains by measuring the correlation between diffusivity in multiple directions. Time dependence of the diffusion is another effect reflecting the dimensions and distributions of barriers. In this paper we extend on DDE with a modified version of the oscillating gradient spin echo (OGSE) experiment, giving a basic contrast mechanism closely linked to both the temporal diffusion spectrum and the compartment anisotropy. We demonstrate our new method on post mortem brain tissue and show that we retrieve the correct temporal diffusion tensor spectrum in synthetic data from Monte Carlo simulations of random walks in a range of disordered geometries of different sizes and shapes.
Original languageEnglish
Article number2930
JournalScientific Reports
Issue number1
Number of pages12
Publication statusPublished - 2018


Dive into the research topics of 'Magnetic resonance temporal diffusion tensor spectroscopy of disordered anisotropic tissue'. Together they form a unique fingerprint.

Cite this