Magnetic resonance imaging at 3.0 tesla detects more lesions in acute optic neuritis than at 1.5 tesla

Kirsten Nielsen; Egill Rostrup; Jette L. Frederiksen; Stine Knudsen; Henrik K. Mathiesen; Lars G. Hanson; Olaf B. Paulson

Magnetic resonance imaging at 3.0 tesla detects more lesions in acute optic neuritis than at 1.5 tesla

Kirsten Nielsen
, Egill Rostrup
, Jette L. Frederiksen
, Stine Knudsen
, Henrik K. Mathiesen
, Lars G. Hanson
, Olaf B. Paulson

Copenhagen University Hospital Herlev and Gentofte

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Objective: We sought to assess whether magnetic resonance imaging (MRI) at 3.0 T detects more brain lesions in acute optic neuritis (ON) than MRI at 1.5 T. Materials and Methods: Twenty-eight patients with acute ON were scanned at both field-strengths using fast-fluid-attenuated inversion recovery (FLAIR), proton density and T2-weighted turbo spin echo, and T1-weighted spin echo after contrast. In addition, magnetization-prepared rapid acquisition gradient echo (MPRAGE) was obtained after contrast at 3.0 T. Lesion number and volumes were assessed by an observer blind to patient identity and field strength. Results: Scans at 3.0 T showed a significantly increase in number of lesions detected on FLAIR images (P 0.002) relative to scanning at 1.5 T. MPRAGE proved to be suitable for detecting enhancing lesions in ON. Conclusion: The MRI protocol at 3.0 T was more sensitive to hyperintense brain lesions in ON than the standard MRI protocol at 1.5 T.
Keyword: Multiple sclerosis,High field,Optic neuritis,Magnetic resonance imaging,

Original language	English
Journal	Investigative Radiology
Volume	41
Issue number	2
Pages (from-to)	76-82
ISSN	0020-9996
Publication status	Published - 2006
Externally published	Yes

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@article{04b01318c78b4a8ea3d8c392815658b8,

title = "Magnetic resonance imaging at 3.0 tesla detects more lesions in acute optic neuritis than at 1.5 tesla",

abstract = "Objective: We sought to assess whether magnetic resonance imaging (MRI) at 3.0 T detects more brain lesions in acute optic neuritis (ON) than MRI at 1.5 T. Materials and Methods: Twenty-eight patients with acute ON were scanned at both field-strengths using fast-fluid-attenuated inversion recovery (FLAIR), proton density and T2-weighted turbo spin echo, and T1-weighted spin echo after contrast. In addition, magnetization-prepared rapid acquisition gradient echo (MPRAGE) was obtained after contrast at 3.0 T. Lesion number and volumes were assessed by an observer blind to patient identity and field strength. Results: Scans at 3.0 T showed a significantly increase in number of lesions detected on FLAIR images (P 0.002) relative to scanning at 1.5 T. MPRAGE proved to be suitable for detecting enhancing lesions in ON. Conclusion: The MRI protocol at 3.0 T was more sensitive to hyperintense brain lesions in ON than the standard MRI protocol at 1.5 T. Keyword: Multiple sclerosis,High field,Optic neuritis,Magnetic resonance imaging,",

author = "Kirsten Nielsen and Egill Rostrup and Frederiksen, \{Jette L.\} and Stine Knudsen and Mathiesen, \{Henrik K.\} and Hanson, \{Lars G.\} and Paulson, \{Olaf B.\}",

year = "2006",

language = "English",

volume = "41",

pages = "76--82",

journal = "Investigative Radiology",

issn = "0020-9996",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

TY - JOUR

T1 - Magnetic resonance imaging at 3.0 tesla detects more lesions in acute optic neuritis than at 1.5 tesla

AU - Nielsen, Kirsten

AU - Rostrup, Egill

AU - Frederiksen, Jette L.

AU - Knudsen, Stine

AU - Mathiesen, Henrik K.

AU - Hanson, Lars G.

AU - Paulson, Olaf B.

PY - 2006

Y1 - 2006

N2 - Objective: We sought to assess whether magnetic resonance imaging (MRI) at 3.0 T detects more brain lesions in acute optic neuritis (ON) than MRI at 1.5 T. Materials and Methods: Twenty-eight patients with acute ON were scanned at both field-strengths using fast-fluid-attenuated inversion recovery (FLAIR), proton density and T2-weighted turbo spin echo, and T1-weighted spin echo after contrast. In addition, magnetization-prepared rapid acquisition gradient echo (MPRAGE) was obtained after contrast at 3.0 T. Lesion number and volumes were assessed by an observer blind to patient identity and field strength. Results: Scans at 3.0 T showed a significantly increase in number of lesions detected on FLAIR images (P 0.002) relative to scanning at 1.5 T. MPRAGE proved to be suitable for detecting enhancing lesions in ON. Conclusion: The MRI protocol at 3.0 T was more sensitive to hyperintense brain lesions in ON than the standard MRI protocol at 1.5 T. Keyword: Multiple sclerosis,High field,Optic neuritis,Magnetic resonance imaging,

AB - Objective: We sought to assess whether magnetic resonance imaging (MRI) at 3.0 T detects more brain lesions in acute optic neuritis (ON) than MRI at 1.5 T. Materials and Methods: Twenty-eight patients with acute ON were scanned at both field-strengths using fast-fluid-attenuated inversion recovery (FLAIR), proton density and T2-weighted turbo spin echo, and T1-weighted spin echo after contrast. In addition, magnetization-prepared rapid acquisition gradient echo (MPRAGE) was obtained after contrast at 3.0 T. Lesion number and volumes were assessed by an observer blind to patient identity and field strength. Results: Scans at 3.0 T showed a significantly increase in number of lesions detected on FLAIR images (P 0.002) relative to scanning at 1.5 T. MPRAGE proved to be suitable for detecting enhancing lesions in ON. Conclusion: The MRI protocol at 3.0 T was more sensitive to hyperintense brain lesions in ON than the standard MRI protocol at 1.5 T. Keyword: Multiple sclerosis,High field,Optic neuritis,Magnetic resonance imaging,

M3 - Journal article

SN - 0020-9996

VL - 41

SP - 76

EP - 82

JO - Investigative Radiology

JF - Investigative Radiology

IS - 2

ER -

Magnetic resonance imaging at 3.0 tesla detects more lesions in acute optic neuritis than at 1.5 tesla

Abstract

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