Magnetic resonance imaging at 3.0 tesla detects more lesions in acute optic neuritis than at 1.5 tesla

Kirsten Nielsen, Egill Rostrup, Jette L. Frederiksen, Stine Knudsen, Henrik K. Mathiesen, Lars G. Hanson, Olaf B. Paulson

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Objective: We sought to assess whether magnetic resonance imaging (MRI) at 3.0 T detects more brain lesions in acute optic neuritis (ON) than MRI at 1.5 T. Materials and Methods: Twenty-eight patients with acute ON were scanned at both field-strengths using fast-fluid-attenuated inversion recovery (FLAIR), proton density and T2-weighted turbo spin echo, and T1-weighted spin echo after contrast. In addition, magnetization-prepared rapid acquisition gradient echo (MPRAGE) was obtained after contrast at 3.0 T. Lesion number and volumes were assessed by an observer blind to patient identity and field strength. Results: Scans at 3.0 T showed a significantly increase in number of lesions detected on FLAIR images (P 0.002) relative to scanning at 1.5 T. MPRAGE proved to be suitable for detecting enhancing lesions in ON. Conclusion: The MRI protocol at 3.0 T was more sensitive to hyperintense brain lesions in ON than the standard MRI protocol at 1.5 T.
Keyword: Multiple sclerosis,High field,Optic neuritis,Magnetic resonance imaging,
Original languageEnglish
JournalInvestigative Radiology
Volume41
Issue number2
Pages (from-to)76-82
ISSN0020-9996
Publication statusPublished - 2006
Externally publishedYes

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