Abstract
The ability to trap, manipulate and release single cells on a surface is important both for fundamental
studies of cellular processes and for the development of novel lab-on-chip miniaturized tools for
biological and medical applications. In this paper we demonstrate how magnetic domain walls
generated in micro- and nano-structures fabricated on a chip surface can be used to handle single yeast
cells labeled with magnetic beads. In detail, first we show that the proposed approach maintains the
microorganism viable, as proven by monitoring the division of labeled yeast cells trapped by domain
walls over 16 hours. Moreover, we demonstrate the controlled transport and release of individual yeast
cells via displacement and annihilation of individual domain walls in micro- and nano-sized magnetic
structures. These results pave the way to the implementation of magnetic devices based on domain walls
technology in lab-on-chip systems devoted to accurate individual cell trapping and manipulation.
Original language | English |
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Journal | Lab on a Chip |
Volume | 11 |
Issue number | 17 |
Pages (from-to) | 2976-2983 |
ISSN | 1473-0197 |
DOIs | |
Publication status | Published - 2011 |