Magnetic bead micromixer: Influence of magnetic element geometry and field amplitude

Torsten Lund-Olesen; Bjarke B. Buus; Jakob Howalt; Mikkel Fougt Hansen

doi:10.1063/1.2829401

Magnetic bead micromixer: Influence of magnetic element geometry and field amplitude

Torsten Lund-Olesen, Bjarke B. Buus, Jakob Howalt, Mikkel Fougt Hansen

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Abstract

A scheme for the silicon microfabrication of lab-on-a-chip systems with mixing based on dynamic plugs of magnetic beads is presented. The systems consist of a microfluidic channel integrated with a number of soft magnetic elements by the sides of the channel. The elements are magnetized by a homogeneous external ac magnetic field. The systems are scalable with respect to the number of magnetic bead plugs and number of parallel channels, and thus they have high potential for use in biological separation using functionalized magnetic beads. The mixing efficiency is characterized for two different geometries of the soft magnetic structures and found to be highly sensitive to the geometry and position of the structures.

Original language	English
Journal	Journal of Applied Physics
Volume	103
Issue number	7
Pages (from-to)	07E902
ISSN	0021-8979
DOIs	https://doi.org/10.1063/1.2829401
Publication status	Published - 2008

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Copyright (2008) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.

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abstract = "A scheme for the silicon microfabrication of lab-on-a-chip systems with mixing based on dynamic plugs of magnetic beads is presented. The systems consist of a microfluidic channel integrated with a number of soft magnetic elements by the sides of the channel. The elements are magnetized by a homogeneous external ac magnetic field. The systems are scalable with respect to the number of magnetic bead plugs and number of parallel channels, and thus they have high potential for use in biological separation using functionalized magnetic beads. The mixing efficiency is characterized for two different geometries of the soft magnetic structures and found to be highly sensitive to the geometry and position of the structures.",

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AU - Lund-Olesen, Torsten

AU - Buus, Bjarke B.

AU - Howalt, Jakob

AU - Hansen, Mikkel Fougt

N1 - Copyright (2008) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.

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N2 - A scheme for the silicon microfabrication of lab-on-a-chip systems with mixing based on dynamic plugs of magnetic beads is presented. The systems consist of a microfluidic channel integrated with a number of soft magnetic elements by the sides of the channel. The elements are magnetized by a homogeneous external ac magnetic field. The systems are scalable with respect to the number of magnetic bead plugs and number of parallel channels, and thus they have high potential for use in biological separation using functionalized magnetic beads. The mixing efficiency is characterized for two different geometries of the soft magnetic structures and found to be highly sensitive to the geometry and position of the structures.

AB - A scheme for the silicon microfabrication of lab-on-a-chip systems with mixing based on dynamic plugs of magnetic beads is presented. The systems consist of a microfluidic channel integrated with a number of soft magnetic elements by the sides of the channel. The elements are magnetized by a homogeneous external ac magnetic field. The systems are scalable with respect to the number of magnetic bead plugs and number of parallel channels, and thus they have high potential for use in biological separation using functionalized magnetic beads. The mixing efficiency is characterized for two different geometries of the soft magnetic structures and found to be highly sensitive to the geometry and position of the structures.

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DO - 10.1063/1.2829401

M3 - Journal article

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SP - 07E902

JO - Journal of Applied Physics

JF - Journal of Applied Physics

IS - 7

ER -

Magnetic bead micromixer: Influence of magnetic element geometry and field amplitude

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