Macrophage-derived osteopontin is fragmented by MMP-9 to hinder angiogenesis in the post-myocardial infarction left ventricle

Signe Holm Nielsen, E.R. Flynn, M. Lindsey

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Abstract

Extracellular matrix (ECM) turnover is a key event during remodeling of the left ventricle (LV) following myocardial infarction (MI). Turnover includes ECM degradation of existing ECM to remove necrotic myocytes and synthesis to produce new ECM to form the infarct scar. Matrix metalloproteinases (MMPs) are elevated post-MI, and MMP-9 has a strong link to post-MI LV dysfunction. The ECM protein osteopontin (OPN) increases post-MI, and we previously identified by mass spectrometry a novel MMP-9 cleavage site of OPN between amino acids 151 and 152. In vitro, peptides both upstream and downstream of the cleavage site increased cardiac fibroblast migration without affecting proliferation.
Original languageEnglish
Article numberP1566
JournalEuropean Heart Journal
Volume38
Issue numberSuppl. 1
Pages (from-to)331
ISSN0195-668X
DOIs
Publication statusPublished - 2017
EventESC Congress 2017: 40 Years of PCI - Barcelona, Spain
Duration: 26 Aug 201730 Aug 2017
https://www.escardio.org/Congresses-%26-Events/ESC-Congress

Conference

ConferenceESC Congress 2017
CountrySpain
CityBarcelona
Period26/08/201730/08/2017
Internet address

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