Low dose effects and non-monotonic dose responses for endocrine active chemicals: Science to practice workshop: Workshop summary

Claire Beausoleil, Jean-Nicolas Ormsby, Andreas Gies, Ulla Hass, Jerrold J. Heindel, Marie Louise Holmer, Pia Juul Nielsen, Sharon Munn, Gilbert Schoenfelder

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Abstract

A workshop was held in Berlin September 12–14th 2012 to assess the state of the science of the data supporting low dose effects and non-monotonic dose responses (“low dose hypothesis”) for chemicals with endocrine activity (endocrine disrupting chemicals or EDCs). This workshop consisted of lectures to present the current state of the science of EDC action and also the risk assessment process. These lectures were followed by breakout sessions to integrate scientists from various backgrounds to discuss in an open and unbiased manner the data supporting the “low dose hypothesis”. While no consensus was reached the robust discussions were helpful to inform both basic scientists and risk assessors on all the issues. There were a number of important ideas developed to help continue the discussion and improve communication over the next few years.
Original languageEnglish
JournalChemosphere
Volume93
Issue number6
Pages (from-to)847-856
ISSN0045-6535
DOIs
Publication statusPublished - 2013

Keywords

  • Low dose effects
  • Non-monotonic dose responses
  • Endocrine disruptors
  • Risk assessment

Cite this

Beausoleil, C., Ormsby, J-N., Gies, A., Hass, U., Heindel, J. J., Holmer, M. L., Nielsen, P. J., Munn, S., & Schoenfelder, G. (2013). Low dose effects and non-monotonic dose responses for endocrine active chemicals: Science to practice workshop: Workshop summary. Chemosphere, 93(6), 847-856. https://doi.org/10.1016/j.chemosphere.2013.06.043