Low-Cost Fabrication of Hollow Microneedle Arrays Using CNC Machining and UV Lithography

Hoà Lê Thanh, B.Q. Ta, H. Le The, V. Nguyen, Kaiying Wang, Frank Karlsen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    In order to produce disposable microneedles for blood-collection devices in smart homecare monitoring systems, we have developed a simple low-cost scalable process for mass fabrication of sharp-tipped microneedle arrays. The key feature in this process is a design of computer numerical control-machined aluminum sample (CAS). The inclined sidewalls on the CAS enable microfabricated traditional-shaped microneedles (TMNs) to be produced in the desired shape. This process provides significant advantages over other methods that use inclined lithography or anisotropic wet etching. TMNs with a length of 1510 mu m, a hollow diameter of 120 mu m, and the tip radius of 16 mu m were successfully fabricated. Theoretical study and practical measurements of fracture force verified the improved mechanical strength of TMNs for safe skin insertion. In addition, the penetration tests on cadaver pork skin demonstrated that the TMNs could pierce the pork skin without breaking, and create the transport conduits through microneedle lumens. [2014-0361]
    Original languageEnglish
    JournalI E E E Journal of Microelectromechanical Systems
    Volume24
    Issue number5
    Pages (from-to)1583-1593
    Number of pages11
    ISSN1057-7157
    DOIs
    Publication statusPublished - 2015

    Cite this

    Lê Thanh, Hoà ; Ta, B.Q. ; Le The, H. ; Nguyen, V. ; Wang, Kaiying ; Karlsen, Frank. / Low-Cost Fabrication of Hollow Microneedle Arrays Using CNC Machining and UV Lithography. In: I E E E Journal of Microelectromechanical Systems. 2015 ; Vol. 24, No. 5. pp. 1583-1593.
    @article{e748b6e228ac4fe594847f5944e35966,
    title = "Low-Cost Fabrication of Hollow Microneedle Arrays Using CNC Machining and UV Lithography",
    abstract = "In order to produce disposable microneedles for blood-collection devices in smart homecare monitoring systems, we have developed a simple low-cost scalable process for mass fabrication of sharp-tipped microneedle arrays. The key feature in this process is a design of computer numerical control-machined aluminum sample (CAS). The inclined sidewalls on the CAS enable microfabricated traditional-shaped microneedles (TMNs) to be produced in the desired shape. This process provides significant advantages over other methods that use inclined lithography or anisotropic wet etching. TMNs with a length of 1510 mu m, a hollow diameter of 120 mu m, and the tip radius of 16 mu m were successfully fabricated. Theoretical study and practical measurements of fracture force verified the improved mechanical strength of TMNs for safe skin insertion. In addition, the penetration tests on cadaver pork skin demonstrated that the TMNs could pierce the pork skin without breaking, and create the transport conduits through microneedle lumens. [2014-0361]",
    author = "{L{\^e} Thanh}, Ho{\`a} and B.Q. Ta and {Le The}, H. and V. Nguyen and Kaiying Wang and Frank Karlsen",
    year = "2015",
    doi = "10.1109/jmems.2015.2424926",
    language = "English",
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    pages = "1583--1593",
    journal = "I E E E Journal of Microelectromechanical Systems",
    issn = "1057-7157",
    publisher = "Institute of Electrical and Electronics Engineers",
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    Low-Cost Fabrication of Hollow Microneedle Arrays Using CNC Machining and UV Lithography. / Lê Thanh, Hoà; Ta, B.Q.; Le The, H.; Nguyen, V.; Wang, Kaiying; Karlsen, Frank.

    In: I E E E Journal of Microelectromechanical Systems, Vol. 24, No. 5, 2015, p. 1583-1593.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - Low-Cost Fabrication of Hollow Microneedle Arrays Using CNC Machining and UV Lithography

    AU - Lê Thanh, Hoà

    AU - Ta, B.Q.

    AU - Le The, H.

    AU - Nguyen, V.

    AU - Wang, Kaiying

    AU - Karlsen, Frank

    PY - 2015

    Y1 - 2015

    N2 - In order to produce disposable microneedles for blood-collection devices in smart homecare monitoring systems, we have developed a simple low-cost scalable process for mass fabrication of sharp-tipped microneedle arrays. The key feature in this process is a design of computer numerical control-machined aluminum sample (CAS). The inclined sidewalls on the CAS enable microfabricated traditional-shaped microneedles (TMNs) to be produced in the desired shape. This process provides significant advantages over other methods that use inclined lithography or anisotropic wet etching. TMNs with a length of 1510 mu m, a hollow diameter of 120 mu m, and the tip radius of 16 mu m were successfully fabricated. Theoretical study and practical measurements of fracture force verified the improved mechanical strength of TMNs for safe skin insertion. In addition, the penetration tests on cadaver pork skin demonstrated that the TMNs could pierce the pork skin without breaking, and create the transport conduits through microneedle lumens. [2014-0361]

    AB - In order to produce disposable microneedles for blood-collection devices in smart homecare monitoring systems, we have developed a simple low-cost scalable process for mass fabrication of sharp-tipped microneedle arrays. The key feature in this process is a design of computer numerical control-machined aluminum sample (CAS). The inclined sidewalls on the CAS enable microfabricated traditional-shaped microneedles (TMNs) to be produced in the desired shape. This process provides significant advantages over other methods that use inclined lithography or anisotropic wet etching. TMNs with a length of 1510 mu m, a hollow diameter of 120 mu m, and the tip radius of 16 mu m were successfully fabricated. Theoretical study and practical measurements of fracture force verified the improved mechanical strength of TMNs for safe skin insertion. In addition, the penetration tests on cadaver pork skin demonstrated that the TMNs could pierce the pork skin without breaking, and create the transport conduits through microneedle lumens. [2014-0361]

    U2 - 10.1109/jmems.2015.2424926

    DO - 10.1109/jmems.2015.2424926

    M3 - Journal article

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    SP - 1583

    EP - 1593

    JO - I E E E Journal of Microelectromechanical Systems

    JF - I E E E Journal of Microelectromechanical Systems

    SN - 1057-7157

    IS - 5

    ER -