Longlasting insecticidal nets for prevention of Leishmania donovani infection in India and Nepal: Paired cluster randomised trial

Albert Picado, Shri Prakash Singh, Suman Rijal, Shyam Sundar, Bart Ostyn, François Chappuis, Surendra Uranw, Kamlesh Gidwani, Basudha Khanal, Madhukar Rai, Ishwari Sharma Paudel, Murari Lal Das, Rajiv Kumar, Pankaj Srivastava, Jean Claude Dujardin, Veerle Vanlerberghe, Elisabeth Wreford Andersen, Clive Richard Davies, Marleen Boelaert

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: To test the effectiveness of large scale distribution of longlasting nets treated with insecticide in reducing the incidence of visceral leishmaniasis in India and Nepal. Design Paired cluster randomised controlled trial designed to detect a 50% reduction in incidence of Leishmania donovani infection. Setting Villages in Muzaffarpur district in India and Saptari, Sunsari, and Morang districts in Nepal. Participants 13 intervention and 13 control clusters. 12 691 people were included in the analysis of the main outcome (infection), and 19 810 were enrolled for the secondary (disease) end point. Intervention Longlasting insecticidal nets (treated with deltamethrin) were distributed in the intervention clusters in December 2006. MAIN OUTCOME MEASURES: Infection was determined by direct agglutination test at 12 and 24 months after the intervention in those who had negative results (titre
Original languageEnglish
Article numberc6760
JournalB M J (Clinical Research Edition)
Volume341
Number of pages8
ISSN0959-8138
DOIs
Publication statusPublished - 2010
Externally publishedYes

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