Longlasting insecticidal nets for prevention of Leishmania donovani infection in India and Nepal: Paired cluster randomised trial

Albert Picado; Shri Prakash Singh; Suman Rijal; Shyam Sundar; Bart Ostyn; François Chappuis; Surendra Uranw; Kamlesh Gidwani; Basudha Khanal; Madhukar Rai; Ishwari Sharma Paudel; Murari Lal Das; Rajiv Kumar; Pankaj Srivastava; Jean Claude Dujardin; Veerle Vanlerberghe; Elisabeth Wreford Andersen; Clive Richard Davies; Marleen Boelaert

doi:10.1136/bmj.c6760

Longlasting insecticidal nets for prevention of Leishmania donovani infection in India and Nepal: Paired cluster randomised trial

Albert Picado, Shri Prakash Singh, Suman Rijal, Shyam Sundar, Bart Ostyn, François Chappuis, Surendra Uranw, Kamlesh Gidwani, Basudha Khanal, Madhukar Rai, Ishwari Sharma Paudel, Murari Lal Das, Rajiv Kumar, Pankaj Srivastava, Jean Claude Dujardin, Veerle Vanlerberghe, Elisabeth Wreford Andersen, Clive Richard Davies, Marleen Boelaert

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

OBJECTIVE: To test the effectiveness of large scale distribution of longlasting nets treated with insecticide in reducing the incidence of visceral leishmaniasis in India and Nepal. Design Paired cluster randomised controlled trial designed to detect a 50% reduction in incidence of Leishmania donovani infection. Setting Villages in Muzaffarpur district in India and Saptari, Sunsari, and Morang districts in Nepal. Participants 13 intervention and 13 control clusters. 12 691 people were included in the analysis of the main outcome (infection), and 19 810 were enrolled for the secondary (disease) end point. Intervention Longlasting insecticidal nets (treated with deltamethrin) were distributed in the intervention clusters in December 2006. MAIN OUTCOME MEASURES: Infection was determined by direct agglutination test at 12 and 24 months after the intervention in those who had negative results (titre

Original language	English
Article number	c6760
Journal	B M J (Clinical Research Edition)
Volume	341
Number of pages	8
ISSN	0959-8138
DOIs	https://doi.org/10.1136/bmj.c6760
Publication status	Published - 2010
Externally published	Yes

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10.1136/bmj.c6760

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Picado, A., Singh, S. P., Rijal, S., Sundar, S., Ostyn, B., Chappuis, F., ... Boelaert, M. (2010). Longlasting insecticidal nets for prevention of Leishmania donovani infection in India and Nepal: Paired cluster randomised trial. B M J (Clinical Research Edition), 341, [c6760]. https://doi.org/10.1136/bmj.c6760

Picado, Albert ; Singh, Shri Prakash ; Rijal, Suman ; Sundar, Shyam ; Ostyn, Bart ; Chappuis, François ; Uranw, Surendra ; Gidwani, Kamlesh ; Khanal, Basudha ; Rai, Madhukar ; Paudel, Ishwari Sharma ; Das, Murari Lal ; Kumar, Rajiv ; Srivastava, Pankaj ; Dujardin, Jean Claude ; Vanlerberghe, Veerle ; Andersen, Elisabeth Wreford ; Davies, Clive Richard ; Boelaert, Marleen. / Longlasting insecticidal nets for prevention of Leishmania donovani infection in India and Nepal : Paired cluster randomised trial. In: B M J (Clinical Research Edition). 2010 ; Vol. 341.

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title = "Longlasting insecticidal nets for prevention of Leishmania donovani infection in India and Nepal: Paired cluster randomised trial",

abstract = "OBJECTIVE: To test the effectiveness of large scale distribution of longlasting nets treated with insecticide in reducing the incidence of visceral leishmaniasis in India and Nepal. Design Paired cluster randomised controlled trial designed to detect a 50{\%} reduction in incidence of Leishmania donovani infection. Setting Villages in Muzaffarpur district in India and Saptari, Sunsari, and Morang districts in Nepal. Participants 13 intervention and 13 control clusters. 12 691 people were included in the analysis of the main outcome (infection), and 19 810 were enrolled for the secondary (disease) end point. Intervention Longlasting insecticidal nets (treated with deltamethrin) were distributed in the intervention clusters in December 2006. MAIN OUTCOME MEASURES: Infection was determined by direct agglutination test at 12 and 24 months after the intervention in those who had negative results (titre",

author = "Albert Picado and Singh, {Shri Prakash} and Suman Rijal and Shyam Sundar and Bart Ostyn and Fran{\cc}ois Chappuis and Surendra Uranw and Kamlesh Gidwani and Basudha Khanal and Madhukar Rai and Paudel, {Ishwari Sharma} and Das, {Murari Lal} and Rajiv Kumar and Pankaj Srivastava and Dujardin, {Jean Claude} and Veerle Vanlerberghe and Andersen, {Elisabeth Wreford} and Davies, {Clive Richard} and Marleen Boelaert",

year = "2010",

doi = "10.1136/bmj.c6760",

language = "English",

volume = "341",

journal = "B M J (Clinical Research Edition)",

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Picado, A, Singh, SP, Rijal, S, Sundar, S, Ostyn, B, Chappuis, F, Uranw, S, Gidwani, K, Khanal, B, Rai, M, Paudel, IS, Das, ML, Kumar, R, Srivastava, P, Dujardin, JC, Vanlerberghe, V, Andersen, EW, Davies, CR & Boelaert, M 2010, 'Longlasting insecticidal nets for prevention of Leishmania donovani infection in India and Nepal: Paired cluster randomised trial', B M J (Clinical Research Edition), vol. 341, c6760. https://doi.org/10.1136/bmj.c6760

Longlasting insecticidal nets for prevention of Leishmania donovani infection in India and Nepal : Paired cluster randomised trial. / Picado, Albert; Singh, Shri Prakash; Rijal, Suman; Sundar, Shyam; Ostyn, Bart; Chappuis, François; Uranw, Surendra; Gidwani, Kamlesh; Khanal, Basudha; Rai, Madhukar; Paudel, Ishwari Sharma; Das, Murari Lal; Kumar, Rajiv; Srivastava, Pankaj; Dujardin, Jean Claude; Vanlerberghe, Veerle; Andersen, Elisabeth Wreford; Davies, Clive Richard; Boelaert, Marleen.

In: B M J (Clinical Research Edition), Vol. 341, c6760, 2010.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Longlasting insecticidal nets for prevention of Leishmania donovani infection in India and Nepal

T2 - Paired cluster randomised trial

AU - Picado, Albert

AU - Singh, Shri Prakash

AU - Rijal, Suman

AU - Sundar, Shyam

AU - Ostyn, Bart

AU - Chappuis, François

AU - Uranw, Surendra

AU - Gidwani, Kamlesh

AU - Khanal, Basudha

AU - Rai, Madhukar

AU - Paudel, Ishwari Sharma

AU - Das, Murari Lal

AU - Kumar, Rajiv

AU - Srivastava, Pankaj

AU - Dujardin, Jean Claude

AU - Vanlerberghe, Veerle

AU - Andersen, Elisabeth Wreford

AU - Davies, Clive Richard

AU - Boelaert, Marleen

PY - 2010

Y1 - 2010

N2 - OBJECTIVE: To test the effectiveness of large scale distribution of longlasting nets treated with insecticide in reducing the incidence of visceral leishmaniasis in India and Nepal. Design Paired cluster randomised controlled trial designed to detect a 50% reduction in incidence of Leishmania donovani infection. Setting Villages in Muzaffarpur district in India and Saptari, Sunsari, and Morang districts in Nepal. Participants 13 intervention and 13 control clusters. 12 691 people were included in the analysis of the main outcome (infection), and 19 810 were enrolled for the secondary (disease) end point. Intervention Longlasting insecticidal nets (treated with deltamethrin) were distributed in the intervention clusters in December 2006. MAIN OUTCOME MEASURES: Infection was determined by direct agglutination test at 12 and 24 months after the intervention in those who had negative results (titre

AB - OBJECTIVE: To test the effectiveness of large scale distribution of longlasting nets treated with insecticide in reducing the incidence of visceral leishmaniasis in India and Nepal. Design Paired cluster randomised controlled trial designed to detect a 50% reduction in incidence of Leishmania donovani infection. Setting Villages in Muzaffarpur district in India and Saptari, Sunsari, and Morang districts in Nepal. Participants 13 intervention and 13 control clusters. 12 691 people were included in the analysis of the main outcome (infection), and 19 810 were enrolled for the secondary (disease) end point. Intervention Longlasting insecticidal nets (treated with deltamethrin) were distributed in the intervention clusters in December 2006. MAIN OUTCOME MEASURES: Infection was determined by direct agglutination test at 12 and 24 months after the intervention in those who had negative results (titre

U2 - 10.1136/bmj.c6760

DO - 10.1136/bmj.c6760

M3 - Journal article

VL - 341

JO - B M J (Clinical Research Edition)

JF - B M J (Clinical Research Edition)

SN - 0959-8138

M1 - c6760

ER -