Long wavelength identification of microcalcifications in breast cancer tissue using a quantum cascade laser and upconversion detection

Yu-Pei Tseng, P. Bouzy, N. Stone, Christian Pedersen, Peter Tidemand-Lichtenberg

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    Abstract

    Spectral imaging in the long-wave infrared regime has great potential for medical diagnostics. Breast cancer is the most common cancer amongst females in the US. The pathological features and the occurrence of the microcalcifications are still poorly understood. However, two types of microcalcifications have been identified as unique biomarkers: type I consisting of calcium oxalate (benign lesions) and type II composed of hydroxyapatite (benign or invasive lesions). In this study, we propose a new approach based on vibrational spectroscopy that is non-destructive, label-free and chemically specific for breast cancer detection. Long-wave infrared spectroscopy combining quantum cascade lasers (QCL) and upconversion detection, offer to improve signal-to-noise ratios compared to standard long-wave infrared
    spectroscopy. We demonstrated long-wave identification of synthetic samples of carbonated hydroxyapatite and of microcalcification in breast cancer tissue using upconversion detection. Absorbance spectra and upconverted images of in situ breast cancer biopsy are compared with that of Fourier-transform infrared (FTIR) spectroscopy.
    Original languageEnglish
    Title of host publicationProceedings of SPIE
    Number of pages7
    PublisherSPIE - International Society for Optical Engineering
    Publication date2018
    Article number104900F
    ISBN (Print)9781510614659
    DOIs
    Publication statusPublished - 2018
    EventBiomedical Vibrational Spectroscopy 2018: Advances in Research and Industry - The Moscone Center, San Francisco, United States
    Duration: 27 Jan 201828 Jan 2018

    Conference

    ConferenceBiomedical Vibrational Spectroscopy 2018
    LocationThe Moscone Center
    Country/TerritoryUnited States
    CitySan Francisco
    Period27/01/201828/01/2018
    SeriesProceedings of SPIE - The International Society for Optical Engineering
    ISSN0277-786X

    Keywords

    • Upconversion
    • Infrared image
    • Medical optics

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