Long wavelength identification of microcalcifications in breast cancer tissue using a quantum cascade laser and upconversion detection

Yu-Pei Tseng, P. Bouzy, N. Stone, Christian Pedersen, Peter Tidemand-Lichtenberg

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Abstract

Spectral imaging in the long-wave infrared regime has great potential for medical diagnostics. Breast cancer is the most common cancer amongst females in the US. The pathological features and the occurrence of the microcalcifications are still poorly understood. However, two types of microcalcifications have been identified as unique biomarkers: type I consisting of calcium oxalate (benign lesions) and type II composed of hydroxyapatite (benign or invasive lesions). In this study, we propose a new approach based on vibrational spectroscopy that is non-destructive, label-free and chemically specific for breast cancer detection. Long-wave infrared spectroscopy combining quantum cascade lasers (QCL) and upconversion detection, offer to improve signal-to-noise ratios compared to standard long-wave infrared
spectroscopy. We demonstrated long-wave identification of synthetic samples of carbonated hydroxyapatite and of microcalcification in breast cancer tissue using upconversion detection. Absorbance spectra and upconverted images of in situ breast cancer biopsy are compared with that of Fourier-transform infrared (FTIR) spectroscopy.
Original languageEnglish
Title of host publicationProceedings of SPIE
Number of pages7
PublisherSPIE - International Society for Optical Engineering
Publication date2018
Article number104900F
ISBN (Print)9781510614659
DOIs
Publication statusPublished - 2018
EventBiomedical Vibrational Spectroscopy 2018: Advances in Research and Industry - The Moscone Center, San Francisco, United States
Duration: 27 Jan 201828 Jan 2018

Conference

ConferenceBiomedical Vibrational Spectroscopy 2018: Advances in Research and Industry
LocationThe Moscone Center
CountryUnited States
CitySan Francisco
Period27/01/201828/01/2018
SeriesProceedings of SPIE, the International Society for Optical Engineering
Volume10490
ISSN0277-786X

Keywords

  • Upconversion
  • Infrared image
  • Medical optics

Cite this

Tseng, Y-P., Bouzy, P., Stone, N., Pedersen, C., & Tidemand-Lichtenberg, P. (2018). Long wavelength identification of microcalcifications in breast cancer tissue using a quantum cascade laser and upconversion detection. In Proceedings of SPIE [104900F] SPIE - International Society for Optical Engineering. Proceedings of SPIE, the International Society for Optical Engineering, Vol.. 10490 https://doi.org/10.1117/12.2290928