The intravaginal route of administration can be exploited to treat local diseases and for systemic delivery. In this work, we developed an alginate/chitosan membrane sufficiently stable in a simulated vaginal fluid and able to dissolve over time at a very slow and linear rate. The membrane demonstrated good mechanical properties both in its swollen and dry form. As a study case, we evaluated the viability of this potential drug delivery system for the treatment of bacterial vaginosis, a common disease affecting women in their reproductive age. Metronidazole was effectively included in the alginate/chitosan membrane and its bactericide effect was demonstrated against Staphylococcus aureus and Gardnerella vaginalis, simultaneously showing good biocompatibility with a cervix epithelial cell line. Since this alginate/chitosan membrane is stable in a simulated vaginal environment, is easy to fabricate and can be used for the controlled release of a model drug, it represents a promising drug delivery system for local intravaginal applications.
|Journal||Journal of Materials Science: Materials in Medicine|
|Number of pages||12|
|Publication status||Published - 2020|
Tentor, F., Siccardi, G., Sacco, P., Demarchi, D., Marsich, E., Almdal, K., Bose-Goswami, S., & Boisen, A. (2020). Long lasting mucoadhesive membrane based on alginate and chitosan for intravaginal drug delivery. Journal of Materials Science: Materials in Medicine, 31(3), . https://doi.org/10.1007/s10856-020-6359-y