Long lasting mucoadhesive membrane based on alginate and chitosan for intravaginal drug delivery

Fabio Tentor*, Giorgia Siccardi, Pasquale Sacco, Danilo Demarchi, Eleonora Marsich, Kristoffer Almdal, Sanjukta Bose-Goswami, Anja Boisen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The intravaginal route of administration can be exploited to treat local diseases and for systemic delivery. In this work, we developed an alginate/chitosan membrane sufficiently stable in a simulated vaginal fluid and able to dissolve over time at a very slow and linear rate. The membrane demonstrated good mechanical properties both in its swollen and dry form. As a study case, we evaluated the viability of this potential drug delivery system for the treatment of bacterial vaginosis, a common disease affecting women in their reproductive age. Metronidazole was effectively included in the alginate/chitosan membrane and its bactericide effect was demonstrated against Staphylococcus aureus and Gardnerella vaginalis, simultaneously showing good biocompatibility with a cervix epithelial cell line. Since this alginate/chitosan membrane is stable in a simulated vaginal environment, is easy to fabricate and can be used for the controlled release of a model drug, it represents a promising drug delivery system for local intravaginal applications.
Original languageEnglish
Article number25
JournalJournal of Materials Science: Materials in Medicine
Volume31
Issue number3
Number of pages12
ISSN0957-4530
DOIs
Publication statusPublished - 2020

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