Locked and Unlocked Nucleosides in Functional Nucleic Acids

Holger Doessing, Birte Vester

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Abstract

Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes.
Original languageEnglish
JournalMolecules
Volume16
Issue number6
Pages (from-to)4511-4526
ISSN1420-3049
DOIs
Publication statusPublished - 2011
Externally publishedYes

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