Locked and Unlocked Nucleosides in Functional Nucleic Acids

Holger Doessing; Birte Vester

doi:10.3390/molecules16064511

Locked and Unlocked Nucleosides in Functional Nucleic Acids

Holger Doessing, Birte Vester

University of Southern Denmark

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Abstract

Nucleic acids are able to adopt a plethora of structures, many of which are of interest in therapeutics, bio- or nanotechnology. However, structural and biochemical stability is a major concern which has been addressed by incorporating a range of modifications and nucleoside derivatives. This review summarizes the use of locked nucleic acid (LNA) and un-locked nucleic acid (UNA) monomers in functional nucleic acids such as aptamers, ribozymes, and DNAzymes.

Original language	English
Journal	Molecules
Volume	16
Issue number	6
Pages (from-to)	4511-4526
ISSN	1420-3049
DOIs	https://doi.org/10.3390/molecules16064511
Publication status	Published - 2011
Externally published	Yes

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Molecules 16 04511 v2Final published version, 181 KB

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Locked and Unlocked Nucleosides in Functional Nucleic Acids

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