Location of repeat elements in glucansucrases of Leuconostoc and Streptococcus species

Stefan Janecek, Birte Svensson, Roy R. B. Russell

Research output: Contribution to journalJournal articleResearchpeer-review


Glucosyltransferases of oral streptococci, dextransucrases and alternansucrase of Leuconostoc mesenteroides, collectively referred to as glucansucrases, are large extracellular enzymes that synthesise glucans with a variety of structures and properties. A characteristic of all these glucansucrases is the possession of a C-terminal domain consisting of a series of tandem amino acid repeats. These repeat units are thought to interact with glucan but closely resemble the cell wall binding domain motif found in choline binding proteins in Streptococcus pneumoniae and surface-located proteins in a range of other bacteria. Analysis of dextransucrase and alternansucrase sequences has now shown that they also contain these repeat motifs in the N-terminal region, raising questions about their evolutionary origin and functional importance.
Original languageEnglish
JournalF E M S Microbiology Letters
Pages (from-to)53-57
Publication statusPublished - 2000
Externally publishedYes


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