The auditory processes involved in the localization of sounds in rooms are still poorly understood. The present study investigated the auditory system’s across-frequency processing of interaural time differences (ITDs) and the impact of the interaural coherence (IC) of the stimuli in ITD discrimination and localization. First, ITD discrimination thresholds were measured as a function of signal frequency, reference ITD, and IC using critical-band wide noises. The resulting data were fitted with a set of analytical functions and ITD weights were derived using concepts from signal detection theory. Inspired by the weighted-image model [Stern, Zeiberg, and Trahiotis. (1988). J. Acoust. Soc. Am. 84, 156–165], the derived ITD weights were then integrated in a simplified localization model using an optimal combination of ITD information across frequency. To verify this model, a series of localization experiments were conducted using broadband noise in which ITD and IC were varied across frequency. The model predictions were in good agreement with the experimental data, supporting the assumption that the auditory system performs a weighted integration of ITD information across frequency to localize a sound source. The results could be valuable for the design of new paradigms to measure localization in more complex acoustic conditions and may provide constraints for future localization models.