Abstract
For major advances in microfabricated drug delivery systems (DDS), fabrication methods with high throughput using biocompatible polymers are required. Once these DDS are fabricated, loading of drug poses a significant challenge. Here, hot punching is presented as an innovative method for drug loading in microfabricated DDS. The microfabricated DDS are microcontainers fabricated in photoresist SU-8 and biopolymer poly-L-lactic-acid (PLLA). Furosemide (F) drug is embedded in poly-ε-caprolactone (PCL) polymer matrix. This F-PCL drug polymer matrix is loaded in SU-8 and PLLA microcontainers using hot punching with >99% yield. Thus, it is illustrated that hot punching allows high-throughput, parallel loading of 3D polymer microcontainers with drug-polymer matrices in a single process step.
Original language | English |
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Article number | 1600366 |
Journal | Macromolecular Materials & Engineering |
Volume | 302 |
Issue number | 3 |
Number of pages | 6 |
ISSN | 1438-7492 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- Biopolymer
- Drug delivery
- Drug-polymer matrix
- Hot punching
- Microcontainers