Loading of Drug-Polymer Matrices in Microreservoirs for Oral Drug Delivery

Ritika Singh Petersen, Stephan Sylvest Keller, Anja Boisen

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    Abstract

    For major advances in microfabricated drug delivery systems (DDS), fabrication methods with high throughput using biocompatible polymers are required. Once these DDS are fabricated, loading of drug poses a significant challenge. Here, hot punching is presented as an innovative method for drug loading in microfabricated DDS. The microfabricated DDS are microcontainers fabricated in photoresist SU-8 and biopolymer poly-L-lactic-acid (PLLA). Furosemide (F) drug is embedded in poly-ε-caprolactone (PCL) polymer matrix. This F-PCL drug polymer matrix is loaded in SU-8 and PLLA microcontainers using hot punching with >99% yield. Thus, it is illustrated that hot punching allows high-throughput, parallel loading of 3D polymer microcontainers with drug-polymer matrices in a single process step.
    Original languageEnglish
    Article number1600366
    JournalMacromolecular Materials & Engineering
    Volume302
    Issue number3
    Number of pages6
    ISSN1438-7492
    DOIs
    Publication statusPublished - 2017

    Keywords

    • Biopolymer
    • Drug delivery
    • Drug-polymer matrix
    • Hot punching
    • Microcontainers

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