Liquid–liquid extraction in flow of the radioisotope titanium-45 for positron emission tomography applications

Kristina Søborg Pedersen, Joseph Imbrogno, Jesper Fonslet, Marcella Lusardi, Klavs F. Jensen, Fedor Zhuravlev*

*Corresponding author for this work

    Research output: Contribution to journalJournal articleResearchpeer-review

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    Abstract

    A continuous liquid–liquid extraction of natTi and its PET radioisotope 45Ti into an organic phase from 12 M HCl is described. The extraction is completely selective with respect to Sc, which is commonly used as a cyclotron target for 45Ti production. A membrane-based separator with integrated pressure control allowed for efficient, reproducible, and robust aqueous/organic phase separation in flow. Optimization studies established a guaiacol–anisole 9/1 (v/v) mixture and a flow rate ratio of 1/3 (aq. to org.), with a residence time of 13.7 s as the optimal extraction conditions. 90.3 ± 1.1% of natTi was consistently extracted from a 0.01 M solution of natTiCl4 and ScCl3, while 84.8 ± 2.4% of 45Ti was extracted from 0.03–0.13 M ScCl3 containing picomolar amounts of the 45Ti radionuclide, without extracting any Sc from either system. The organic phase can be directly used for 45Ti-radiolabelling as demonstrated by the efficient radiosynthesis of the 45Ti-radiolabeled antineoplastic [45Ti]IJsalan)TiIJdipic). This development opens a pathway to achieve continuous and efficient 45Ti recovery and processing using an automated micro or millifluidics setup.
    Original languageEnglish
    JournalReaction Chemistry and Engineering
    Volume3
    Issue number6
    Pages (from-to)898-904
    ISSN2058-9883
    DOIs
    Publication statusPublished - 2018

    Cite this

    @article{f2df3b80bd7a474787f2a5217dc96597,
    title = "Liquid–liquid extraction in flow of the radioisotope titanium-45 for positron emission tomography applications",
    abstract = "A continuous liquid–liquid extraction of natTi and its PET radioisotope 45Ti into an organic phase from 12 M HCl is described. The extraction is completely selective with respect to Sc, which is commonly used as a cyclotron target for 45Ti production. A membrane-based separator with integrated pressure control allowed for efficient, reproducible, and robust aqueous/organic phase separation in flow. Optimization studies established a guaiacol–anisole 9/1 (v/v) mixture and a flow rate ratio of 1/3 (aq. to org.), with a residence time of 13.7 s as the optimal extraction conditions. 90.3 ± 1.1{\%} of natTi was consistently extracted from a 0.01 M solution of natTiCl4 and ScCl3, while 84.8 ± 2.4{\%} of 45Ti was extracted from 0.03–0.13 M ScCl3 containing picomolar amounts of the 45Ti radionuclide, without extracting any Sc from either system. The organic phase can be directly used for 45Ti-radiolabelling as demonstrated by the efficient radiosynthesis of the 45Ti-radiolabeled antineoplastic [45Ti]IJsalan)TiIJdipic). This development opens a pathway to achieve continuous and efficient 45Ti recovery and processing using an automated micro or millifluidics setup.",
    author = "Pedersen, {Kristina S{\o}borg} and Joseph Imbrogno and Jesper Fonslet and Marcella Lusardi and Jensen, {Klavs F.} and Fedor Zhuravlev",
    year = "2018",
    doi = "10.1039/C8RE00175H",
    language = "English",
    volume = "3",
    pages = "898--904",
    journal = "Reaction Chemistry & Engineering",
    issn = "2058-9883",
    publisher = "Royal Society of Chemistry",
    number = "6",

    }

    Liquid–liquid extraction in flow of the radioisotope titanium-45 for positron emission tomography applications. / Pedersen, Kristina Søborg; Imbrogno, Joseph; Fonslet, Jesper; Lusardi, Marcella; Jensen, Klavs F.; Zhuravlev, Fedor.

    In: Reaction Chemistry and Engineering, Vol. 3, No. 6, 2018, p. 898-904.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - Liquid–liquid extraction in flow of the radioisotope titanium-45 for positron emission tomography applications

    AU - Pedersen, Kristina Søborg

    AU - Imbrogno, Joseph

    AU - Fonslet, Jesper

    AU - Lusardi, Marcella

    AU - Jensen, Klavs F.

    AU - Zhuravlev, Fedor

    PY - 2018

    Y1 - 2018

    N2 - A continuous liquid–liquid extraction of natTi and its PET radioisotope 45Ti into an organic phase from 12 M HCl is described. The extraction is completely selective with respect to Sc, which is commonly used as a cyclotron target for 45Ti production. A membrane-based separator with integrated pressure control allowed for efficient, reproducible, and robust aqueous/organic phase separation in flow. Optimization studies established a guaiacol–anisole 9/1 (v/v) mixture and a flow rate ratio of 1/3 (aq. to org.), with a residence time of 13.7 s as the optimal extraction conditions. 90.3 ± 1.1% of natTi was consistently extracted from a 0.01 M solution of natTiCl4 and ScCl3, while 84.8 ± 2.4% of 45Ti was extracted from 0.03–0.13 M ScCl3 containing picomolar amounts of the 45Ti radionuclide, without extracting any Sc from either system. The organic phase can be directly used for 45Ti-radiolabelling as demonstrated by the efficient radiosynthesis of the 45Ti-radiolabeled antineoplastic [45Ti]IJsalan)TiIJdipic). This development opens a pathway to achieve continuous and efficient 45Ti recovery and processing using an automated micro or millifluidics setup.

    AB - A continuous liquid–liquid extraction of natTi and its PET radioisotope 45Ti into an organic phase from 12 M HCl is described. The extraction is completely selective with respect to Sc, which is commonly used as a cyclotron target for 45Ti production. A membrane-based separator with integrated pressure control allowed for efficient, reproducible, and robust aqueous/organic phase separation in flow. Optimization studies established a guaiacol–anisole 9/1 (v/v) mixture and a flow rate ratio of 1/3 (aq. to org.), with a residence time of 13.7 s as the optimal extraction conditions. 90.3 ± 1.1% of natTi was consistently extracted from a 0.01 M solution of natTiCl4 and ScCl3, while 84.8 ± 2.4% of 45Ti was extracted from 0.03–0.13 M ScCl3 containing picomolar amounts of the 45Ti radionuclide, without extracting any Sc from either system. The organic phase can be directly used for 45Ti-radiolabelling as demonstrated by the efficient radiosynthesis of the 45Ti-radiolabeled antineoplastic [45Ti]IJsalan)TiIJdipic). This development opens a pathway to achieve continuous and efficient 45Ti recovery and processing using an automated micro or millifluidics setup.

    U2 - 10.1039/C8RE00175H

    DO - 10.1039/C8RE00175H

    M3 - Journal article

    VL - 3

    SP - 898

    EP - 904

    JO - Reaction Chemistry & Engineering

    JF - Reaction Chemistry & Engineering

    SN - 2058-9883

    IS - 6

    ER -