Abstract
| Original language | English |
|---|---|
| Journal | Reaction Chemistry and Engineering |
| Volume | 3 |
| Issue number | 6 |
| Pages (from-to) | 898-904 |
| ISSN | 2058-9883 |
| DOIs | |
| Publication status | Published - 2018 |
Cite this
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Liquid–liquid extraction in flow of the radioisotope titanium-45 for positron emission tomography applications. / Pedersen, Kristina Søborg; Imbrogno, Joseph; Fonslet, Jesper; Lusardi, Marcella; Jensen, Klavs F.; Zhuravlev, Fedor.
In: Reaction Chemistry and Engineering, Vol. 3, No. 6, 2018, p. 898-904.Research output: Contribution to journal › Journal article › Research › peer-review
TY - JOUR
T1 - Liquid–liquid extraction in flow of the radioisotope titanium-45 for positron emission tomography applications
AU - Pedersen, Kristina Søborg
AU - Imbrogno, Joseph
AU - Fonslet, Jesper
AU - Lusardi, Marcella
AU - Jensen, Klavs F.
AU - Zhuravlev, Fedor
PY - 2018
Y1 - 2018
N2 - A continuous liquid–liquid extraction of natTi and its PET radioisotope 45Ti into an organic phase from 12 M HCl is described. The extraction is completely selective with respect to Sc, which is commonly used as a cyclotron target for 45Ti production. A membrane-based separator with integrated pressure control allowed for efficient, reproducible, and robust aqueous/organic phase separation in flow. Optimization studies established a guaiacol–anisole 9/1 (v/v) mixture and a flow rate ratio of 1/3 (aq. to org.), with a residence time of 13.7 s as the optimal extraction conditions. 90.3 ± 1.1% of natTi was consistently extracted from a 0.01 M solution of natTiCl4 and ScCl3, while 84.8 ± 2.4% of 45Ti was extracted from 0.03–0.13 M ScCl3 containing picomolar amounts of the 45Ti radionuclide, without extracting any Sc from either system. The organic phase can be directly used for 45Ti-radiolabelling as demonstrated by the efficient radiosynthesis of the 45Ti-radiolabeled antineoplastic [45Ti]IJsalan)TiIJdipic). This development opens a pathway to achieve continuous and efficient 45Ti recovery and processing using an automated micro or millifluidics setup.
AB - A continuous liquid–liquid extraction of natTi and its PET radioisotope 45Ti into an organic phase from 12 M HCl is described. The extraction is completely selective with respect to Sc, which is commonly used as a cyclotron target for 45Ti production. A membrane-based separator with integrated pressure control allowed for efficient, reproducible, and robust aqueous/organic phase separation in flow. Optimization studies established a guaiacol–anisole 9/1 (v/v) mixture and a flow rate ratio of 1/3 (aq. to org.), with a residence time of 13.7 s as the optimal extraction conditions. 90.3 ± 1.1% of natTi was consistently extracted from a 0.01 M solution of natTiCl4 and ScCl3, while 84.8 ± 2.4% of 45Ti was extracted from 0.03–0.13 M ScCl3 containing picomolar amounts of the 45Ti radionuclide, without extracting any Sc from either system. The organic phase can be directly used for 45Ti-radiolabelling as demonstrated by the efficient radiosynthesis of the 45Ti-radiolabeled antineoplastic [45Ti]IJsalan)TiIJdipic). This development opens a pathway to achieve continuous and efficient 45Ti recovery and processing using an automated micro or millifluidics setup.
U2 - 10.1039/C8RE00175H
DO - 10.1039/C8RE00175H
M3 - Journal article
VL - 3
SP - 898
EP - 904
JO - Reaction Chemistry & Engineering
JF - Reaction Chemistry & Engineering
SN - 2058-9883
IS - 6
ER -