Liquid–liquid extraction in flow of the radioisotope titanium-45 for positron emission tomography applications

Kristina Søborg Pedersen, Joseph Imbrogno, Jesper Fonslet, Marcella Lusardi, Klavs F. Jensen, Fedor Zhuravlev*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

A continuous liquid–liquid extraction of natTi and its PET radioisotope 45Ti into an organic phase from 12 M HCl is described. The extraction is completely selective with respect to Sc, which is commonly used as a cyclotron target for 45Ti production. A membrane-based separator with integrated pressure control allowed for efficient, reproducible, and robust aqueous/organic phase separation in flow. Optimization studies established a guaiacol–anisole 9/1 (v/v) mixture and a flow rate ratio of 1/3 (aq. to org.), with a residence time of 13.7 s as the optimal extraction conditions. 90.3 ± 1.1% of natTi was consistently extracted from a 0.01 M solution of natTiCl4 and ScCl3, while 84.8 ± 2.4% of 45Ti was extracted from 0.03–0.13 M ScCl3 containing picomolar amounts of the 45Ti radionuclide, without extracting any Sc from either system. The organic phase can be directly used for 45Ti-radiolabelling as demonstrated by the efficient radiosynthesis of the 45Ti-radiolabeled antineoplastic [45Ti]IJsalan)TiIJdipic). This development opens a pathway to achieve continuous and efficient 45Ti recovery and processing using an automated micro or millifluidics setup.
Original languageEnglish
JournalReaction Chemistry and Engineering
Volume3
Issue number6
Pages (from-to)898-904
ISSN2058-9883
DOIs
Publication statusPublished - 2018

Cite this

@article{f2df3b80bd7a474787f2a5217dc96597,
title = "Liquid–liquid extraction in flow of the radioisotope titanium-45 for positron emission tomography applications",
abstract = "A continuous liquid–liquid extraction of natTi and its PET radioisotope 45Ti into an organic phase from 12 M HCl is described. The extraction is completely selective with respect to Sc, which is commonly used as a cyclotron target for 45Ti production. A membrane-based separator with integrated pressure control allowed for efficient, reproducible, and robust aqueous/organic phase separation in flow. Optimization studies established a guaiacol–anisole 9/1 (v/v) mixture and a flow rate ratio of 1/3 (aq. to org.), with a residence time of 13.7 s as the optimal extraction conditions. 90.3 ± 1.1{\%} of natTi was consistently extracted from a 0.01 M solution of natTiCl4 and ScCl3, while 84.8 ± 2.4{\%} of 45Ti was extracted from 0.03–0.13 M ScCl3 containing picomolar amounts of the 45Ti radionuclide, without extracting any Sc from either system. The organic phase can be directly used for 45Ti-radiolabelling as demonstrated by the efficient radiosynthesis of the 45Ti-radiolabeled antineoplastic [45Ti]IJsalan)TiIJdipic). This development opens a pathway to achieve continuous and efficient 45Ti recovery and processing using an automated micro or millifluidics setup.",
author = "Pedersen, {Kristina S{\o}borg} and Joseph Imbrogno and Jesper Fonslet and Marcella Lusardi and Jensen, {Klavs F.} and Fedor Zhuravlev",
year = "2018",
doi = "10.1039/C8RE00175H",
language = "English",
volume = "3",
pages = "898--904",
journal = "Reaction Chemistry & Engineering",
issn = "2058-9883",
publisher = "Royal Society of Chemistry",
number = "6",

}

Liquid–liquid extraction in flow of the radioisotope titanium-45 for positron emission tomography applications. / Pedersen, Kristina Søborg; Imbrogno, Joseph; Fonslet, Jesper; Lusardi, Marcella; Jensen, Klavs F.; Zhuravlev, Fedor.

In: Reaction Chemistry and Engineering, Vol. 3, No. 6, 2018, p. 898-904.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Liquid–liquid extraction in flow of the radioisotope titanium-45 for positron emission tomography applications

AU - Pedersen, Kristina Søborg

AU - Imbrogno, Joseph

AU - Fonslet, Jesper

AU - Lusardi, Marcella

AU - Jensen, Klavs F.

AU - Zhuravlev, Fedor

PY - 2018

Y1 - 2018

N2 - A continuous liquid–liquid extraction of natTi and its PET radioisotope 45Ti into an organic phase from 12 M HCl is described. The extraction is completely selective with respect to Sc, which is commonly used as a cyclotron target for 45Ti production. A membrane-based separator with integrated pressure control allowed for efficient, reproducible, and robust aqueous/organic phase separation in flow. Optimization studies established a guaiacol–anisole 9/1 (v/v) mixture and a flow rate ratio of 1/3 (aq. to org.), with a residence time of 13.7 s as the optimal extraction conditions. 90.3 ± 1.1% of natTi was consistently extracted from a 0.01 M solution of natTiCl4 and ScCl3, while 84.8 ± 2.4% of 45Ti was extracted from 0.03–0.13 M ScCl3 containing picomolar amounts of the 45Ti radionuclide, without extracting any Sc from either system. The organic phase can be directly used for 45Ti-radiolabelling as demonstrated by the efficient radiosynthesis of the 45Ti-radiolabeled antineoplastic [45Ti]IJsalan)TiIJdipic). This development opens a pathway to achieve continuous and efficient 45Ti recovery and processing using an automated micro or millifluidics setup.

AB - A continuous liquid–liquid extraction of natTi and its PET radioisotope 45Ti into an organic phase from 12 M HCl is described. The extraction is completely selective with respect to Sc, which is commonly used as a cyclotron target for 45Ti production. A membrane-based separator with integrated pressure control allowed for efficient, reproducible, and robust aqueous/organic phase separation in flow. Optimization studies established a guaiacol–anisole 9/1 (v/v) mixture and a flow rate ratio of 1/3 (aq. to org.), with a residence time of 13.7 s as the optimal extraction conditions. 90.3 ± 1.1% of natTi was consistently extracted from a 0.01 M solution of natTiCl4 and ScCl3, while 84.8 ± 2.4% of 45Ti was extracted from 0.03–0.13 M ScCl3 containing picomolar amounts of the 45Ti radionuclide, without extracting any Sc from either system. The organic phase can be directly used for 45Ti-radiolabelling as demonstrated by the efficient radiosynthesis of the 45Ti-radiolabeled antineoplastic [45Ti]IJsalan)TiIJdipic). This development opens a pathway to achieve continuous and efficient 45Ti recovery and processing using an automated micro or millifluidics setup.

U2 - 10.1039/C8RE00175H

DO - 10.1039/C8RE00175H

M3 - Journal article

VL - 3

SP - 898

EP - 904

JO - Reaction Chemistry & Engineering

JF - Reaction Chemistry & Engineering

SN - 2058-9883

IS - 6

ER -