Liquid-State 13C Polarization of 30% through Photoinduced Nonpersistent Radicals

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Abstract

Hyperpolarization via dissolutiondynamic nuclear polarization(dDNP) is crucial to significantly increasing the magnetic resonanceimaging (MRI) sensitivity, opening up in vivo real-time MRI using 13C-labeled substrates. The range of applications, however,is limited by the relatively fast decay of the nuclear spin polarizationtogether with the constraint of having to polarize the spins nearthe MRI magnet. As recently demonstrated, the employment of UV-inducednonpersistent radicals represents an elegant solution to tacklingthese drawbacks. Nevertheless, since its introduction, the spreadof the technique has been prevented by the relatively low achievablepolarization, slow buildup time, and time-consuming sample preparation.In the present work, thanks to a thorough investigation of the radicalgeneration step, we provide a robust protocol to enhance the efficiencyand performance of the UV-radical technique. Under optimal conditions,it was possible to produce up to 60 mM radical in less than 5 minand reach maximum DNP enhancement with a buildup time constant ofapproximately 25 min at 6.7 T and 1 K, resulting in 30% 13C liquid-state polarization.
Original languageEnglish
JournalJournal of Physical Chemistry C
Volume122
Issue number13
Pages (from-to)7432-7443
ISSN1932-7447
DOIs
Publication statusPublished - 2018

Cite this

@article{b9ab4bc8a5f949619f585cbcbfb00eec,
title = "Liquid-State 13C Polarization of 30{\%} through Photoinduced Nonpersistent Radicals",
abstract = "Hyperpolarization via dissolutiondynamic nuclear polarization(dDNP) is crucial to significantly increasing the magnetic resonanceimaging (MRI) sensitivity, opening up in vivo real-time MRI using 13C-labeled substrates. The range of applications, however,is limited by the relatively fast decay of the nuclear spin polarizationtogether with the constraint of having to polarize the spins nearthe MRI magnet. As recently demonstrated, the employment of UV-inducednonpersistent radicals represents an elegant solution to tacklingthese drawbacks. Nevertheless, since its introduction, the spreadof the technique has been prevented by the relatively low achievablepolarization, slow buildup time, and time-consuming sample preparation.In the present work, thanks to a thorough investigation of the radicalgeneration step, we provide a robust protocol to enhance the efficiencyand performance of the UV-radical technique. Under optimal conditions,it was possible to produce up to 60 mM radical in less than 5 minand reach maximum DNP enhancement with a buildup time constant ofapproximately 25 min at 6.7 T and 1 K, resulting in 30{\%} 13C liquid-state polarization.",
author = "Andrea Capozzi and Magnus Karlsson and Petersen, {Jan Raagaard} and Lerche, {Mathilde Hauge} and Ardenkj{\ae}r-Larsen, {Jan Henrik}",
year = "2018",
doi = "10.1021/acs.jpcc.8b01482",
language = "English",
volume = "122",
pages = "7432--7443",
journal = "The Journal of Physical Chemistry Part C",
issn = "1932-7447",
publisher = "American Chemical Society",
number = "13",

}

TY - JOUR

T1 - Liquid-State 13C Polarization of 30% through Photoinduced Nonpersistent Radicals

AU - Capozzi, Andrea

AU - Karlsson, Magnus

AU - Petersen, Jan Raagaard

AU - Lerche, Mathilde Hauge

AU - Ardenkjær-Larsen, Jan Henrik

PY - 2018

Y1 - 2018

N2 - Hyperpolarization via dissolutiondynamic nuclear polarization(dDNP) is crucial to significantly increasing the magnetic resonanceimaging (MRI) sensitivity, opening up in vivo real-time MRI using 13C-labeled substrates. The range of applications, however,is limited by the relatively fast decay of the nuclear spin polarizationtogether with the constraint of having to polarize the spins nearthe MRI magnet. As recently demonstrated, the employment of UV-inducednonpersistent radicals represents an elegant solution to tacklingthese drawbacks. Nevertheless, since its introduction, the spreadof the technique has been prevented by the relatively low achievablepolarization, slow buildup time, and time-consuming sample preparation.In the present work, thanks to a thorough investigation of the radicalgeneration step, we provide a robust protocol to enhance the efficiencyand performance of the UV-radical technique. Under optimal conditions,it was possible to produce up to 60 mM radical in less than 5 minand reach maximum DNP enhancement with a buildup time constant ofapproximately 25 min at 6.7 T and 1 K, resulting in 30% 13C liquid-state polarization.

AB - Hyperpolarization via dissolutiondynamic nuclear polarization(dDNP) is crucial to significantly increasing the magnetic resonanceimaging (MRI) sensitivity, opening up in vivo real-time MRI using 13C-labeled substrates. The range of applications, however,is limited by the relatively fast decay of the nuclear spin polarizationtogether with the constraint of having to polarize the spins nearthe MRI magnet. As recently demonstrated, the employment of UV-inducednonpersistent radicals represents an elegant solution to tacklingthese drawbacks. Nevertheless, since its introduction, the spreadof the technique has been prevented by the relatively low achievablepolarization, slow buildup time, and time-consuming sample preparation.In the present work, thanks to a thorough investigation of the radicalgeneration step, we provide a robust protocol to enhance the efficiencyand performance of the UV-radical technique. Under optimal conditions,it was possible to produce up to 60 mM radical in less than 5 minand reach maximum DNP enhancement with a buildup time constant ofapproximately 25 min at 6.7 T and 1 K, resulting in 30% 13C liquid-state polarization.

U2 - 10.1021/acs.jpcc.8b01482

DO - 10.1021/acs.jpcc.8b01482

M3 - Journal article

VL - 122

SP - 7432

EP - 7443

JO - The Journal of Physical Chemistry Part C

JF - The Journal of Physical Chemistry Part C

SN - 1932-7447

IS - 13

ER -