Liquid phase chromatography on microchips

Jörg Peter Kutter

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Over the past twenty years, the field of microfluidics has emerged providing one of the main enabling technologies to realize miniaturized chemical analysis systems, often referred to as micro-Total Analysis Systems (uTAS), or, more generally, Lab-on-a-Chip Systems (LOC) [1,2]. While microfluidics was driven forward a lot from the engineering side, especially with respect to ink jet and dispensing technology, the initial push and interest from the analytical chemistry community was through the desire to develop miniaturized sensors, detectors, and, very early on, separation systems. The initial almost explosive development of, in particular, chromatographic separation systems on microchips, has, however, slowed down in recent years. This review takes a closer, critical look at how liquid phase chromatography has been implemented in miniaturized formats over the past several years, what is important to keep in mind when developing or working with separations in a miniaturized format, and what challenges and pitfalls remain.
    Original languageEnglish
    JournalJournal of Chromatography A
    Volume1221
    Pages (from-to)72-82
    ISSN0021-9673
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Lab-on-a-chip
    • Liquid chromatography
    • Review
    • Miniaturization
    • Microchips

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