Liposome accumulation in irradiated tumors display important tumor and dose dependent differences

Anders Elias Hansen, Frederikke Petrine Fliedner, Jonas Rosager Henriksen, Jesper Tranekjær Jørgensen, Andreas Ettrup Clemmensen, Betina Børresen, Dennis Ringkjøbing Elema, Andreas Kjær, Thomas Lars Andresen*

*Corresponding author for this work

    Research output: Contribution to journalJournal articleResearchpeer-review

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    Abstract

    Radiation therapy may affect several important parameters in the tumor microenvironment and thereby influence the accumulation of liposomes by the enhanced permeability and retention (EPR)-effect. Here we investigate the effect of single dose radiation therapy on liposome tumor accumulation by PET/CT imaging using radiolabeled liposomes. Head and neck cancer xenografts (FaDu) and syngenic colorectal (CT26) cancer models were investigated. Radiotherapy displayed opposite effects in the two models. FaDu tumors displayed increased mean accumulation of liposomes for radiation doses up to 10 Gy, whereas CT26 tumors displayed a tendency for decreased accumulation. Tumor hypoxia was found negatively correlated to microregional distribution of liposomes. However, liposome distribution in relation to hypoxia was improved at lower radiation doses. The study reveals that the heterogeneity in liposome tumor accumulation between tumors and different radiation protocols are important factors that need to be taken into consideration to achieve optimal effect of liposome based radio-sensitizer therapy.
    Original languageEnglish
    JournalNanomedicine: Nanotechnology, Biology and Medicine
    Volume14
    Pages (from-to)27–34
    ISSN1549-9634
    DOIs
    Publication statusPublished - 2018

    Keywords

    • Liposome
    • PET
    • Radiotherapy
    • Radio-sensitizer
    • Hypoxia

    Cite this

    Hansen, Anders Elias ; Fliedner, Frederikke Petrine ; Henriksen, Jonas Rosager ; Jørgensen, Jesper Tranekjær ; Clemmensen, Andreas Ettrup ; Børresen, Betina ; Elema, Dennis Ringkjøbing ; Kjær, Andreas ; Andresen, Thomas Lars. / Liposome accumulation in irradiated tumors display important tumor and dose dependent differences. In: Nanomedicine: Nanotechnology, Biology and Medicine. 2018 ; Vol. 14. pp. 27–34.
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    abstract = "Radiation therapy may affect several important parameters in the tumor microenvironment and thereby influence the accumulation of liposomes by the enhanced permeability and retention (EPR)-effect. Here we investigate the effect of single dose radiation therapy on liposome tumor accumulation by PET/CT imaging using radiolabeled liposomes. Head and neck cancer xenografts (FaDu) and syngenic colorectal (CT26) cancer models were investigated. Radiotherapy displayed opposite effects in the two models. FaDu tumors displayed increased mean accumulation of liposomes for radiation doses up to 10 Gy, whereas CT26 tumors displayed a tendency for decreased accumulation. Tumor hypoxia was found negatively correlated to microregional distribution of liposomes. However, liposome distribution in relation to hypoxia was improved at lower radiation doses. The study reveals that the heterogeneity in liposome tumor accumulation between tumors and different radiation protocols are important factors that need to be taken into consideration to achieve optimal effect of liposome based radio-sensitizer therapy.",
    keywords = "Liposome, PET, Radiotherapy, Radio-sensitizer, Hypoxia",
    author = "Hansen, {Anders Elias} and Fliedner, {Frederikke Petrine} and Henriksen, {Jonas Rosager} and J{\o}rgensen, {Jesper Tranekj{\ae}r} and Clemmensen, {Andreas Ettrup} and Betina B{\o}rresen and Elema, {Dennis Ringkj{\o}bing} and Andreas Kj{\ae}r and Andresen, {Thomas Lars}",
    year = "2018",
    doi = "10.1016/j.nano.2017.08.013",
    language = "English",
    volume = "14",
    pages = "27–34",
    journal = "Nanomedicine: Nanotechnology, Biology and Medicine",
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    Liposome accumulation in irradiated tumors display important tumor and dose dependent differences. / Hansen, Anders Elias; Fliedner, Frederikke Petrine; Henriksen, Jonas Rosager; Jørgensen, Jesper Tranekjær; Clemmensen, Andreas Ettrup; Børresen, Betina; Elema, Dennis Ringkjøbing; Kjær, Andreas ; Andresen, Thomas Lars.

    In: Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 14, 2018, p. 27–34.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - Liposome accumulation in irradiated tumors display important tumor and dose dependent differences

    AU - Hansen, Anders Elias

    AU - Fliedner, Frederikke Petrine

    AU - Henriksen, Jonas Rosager

    AU - Jørgensen, Jesper Tranekjær

    AU - Clemmensen, Andreas Ettrup

    AU - Børresen, Betina

    AU - Elema, Dennis Ringkjøbing

    AU - Kjær, Andreas

    AU - Andresen, Thomas Lars

    PY - 2018

    Y1 - 2018

    N2 - Radiation therapy may affect several important parameters in the tumor microenvironment and thereby influence the accumulation of liposomes by the enhanced permeability and retention (EPR)-effect. Here we investigate the effect of single dose radiation therapy on liposome tumor accumulation by PET/CT imaging using radiolabeled liposomes. Head and neck cancer xenografts (FaDu) and syngenic colorectal (CT26) cancer models were investigated. Radiotherapy displayed opposite effects in the two models. FaDu tumors displayed increased mean accumulation of liposomes for radiation doses up to 10 Gy, whereas CT26 tumors displayed a tendency for decreased accumulation. Tumor hypoxia was found negatively correlated to microregional distribution of liposomes. However, liposome distribution in relation to hypoxia was improved at lower radiation doses. The study reveals that the heterogeneity in liposome tumor accumulation between tumors and different radiation protocols are important factors that need to be taken into consideration to achieve optimal effect of liposome based radio-sensitizer therapy.

    AB - Radiation therapy may affect several important parameters in the tumor microenvironment and thereby influence the accumulation of liposomes by the enhanced permeability and retention (EPR)-effect. Here we investigate the effect of single dose radiation therapy on liposome tumor accumulation by PET/CT imaging using radiolabeled liposomes. Head and neck cancer xenografts (FaDu) and syngenic colorectal (CT26) cancer models were investigated. Radiotherapy displayed opposite effects in the two models. FaDu tumors displayed increased mean accumulation of liposomes for radiation doses up to 10 Gy, whereas CT26 tumors displayed a tendency for decreased accumulation. Tumor hypoxia was found negatively correlated to microregional distribution of liposomes. However, liposome distribution in relation to hypoxia was improved at lower radiation doses. The study reveals that the heterogeneity in liposome tumor accumulation between tumors and different radiation protocols are important factors that need to be taken into consideration to achieve optimal effect of liposome based radio-sensitizer therapy.

    KW - Liposome

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    KW - Radiotherapy

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    KW - Hypoxia

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    M3 - Journal article

    C2 - 28882674

    VL - 14

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    EP - 34

    JO - Nanomedicine: Nanotechnology, Biology and Medicine

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