Lipogels: Surface-adherent composite hydrogels assembled from poly(vinyl alcohol) and liposomes

Bettina E. B. Jensen, Leticia Hosta Rigau, Philipp R. Spycher, Erik Reimhult, Brigitte Stadler, Alexander N. Zelikin

Research output: Contribution to journalJournal articleResearchpeer-review

69 Downloads (Pure)

Abstract

Drug-eluting engineered surface coatings are of paramount importance for many biomedical applications from implantable devices to tissue engineering. Herein, we present the assembly of lipogels, composite physical hydrogels assembled from poly(vinyl alcohol) and liposomes using thiol-disulfide exchange between end group modified PVA and thiocholesterol containing liposomes, and the response of adhering cells to these coatings. We demonstrate the controlled loading of liposomes into the polymer matrix and the preserved mechanical properties of the lipogels. Furthermore, the lipogels are successfully rendered cell adhesive by incorporation of poly(L-lysine) into the PVA polymer matrix or by poly(dopamine) coating of the lipogels. The successful lipid uptake from the lipogels by macrophages, hepatocytes, and myoblasts was monitored by flow cytometry. Finally, the delivery of active cargo, paclitaxel, to adherent myoblasts is shown, thus illustrating the potential of the lipogels as a drug eluting interface for biomedical applications.
Original languageEnglish
JournalNanoscale
Volume5
Issue number15
Number of pages11
ISSN2040-3364
DOIs
Publication statusPublished - 2013
Externally publishedYes

Bibliographical note

This journal is © The Royal Society of Chemistry 2013

Fingerprint

Dive into the research topics of 'Lipogels: Surface-adherent composite hydrogels assembled from poly(vinyl alcohol) and liposomes'. Together they form a unique fingerprint.

Cite this