The objective of this study was to determine if the positional structure of dietary triacylglycerol affected lipidemic responses. Thirty healthyadults (16 men and 14 postmenopausal women) with low-density lipoprotein cholesterol (LDL-C) concentrations >3.37 mM (130 mg/dL)enrolled in a prospective, single-blind, cross-over outpatient clinical trial that consisted of two 5-wk dietary phases. After baseline screening,subjects were instructed to follow individualized meal plans (weight maintenance diets with 36% of total energy from fat, half of which wasfrom a test oil) and randomized to receive either butter (B) or an interesterified mixture (IM) of butter, medium-chain triacylglycerol (MCT),and safflower oils. Blood drawn during weeks 5 and 10 of feeding was analyzed for total cholesterol (TC), high density lipoproteincholesterol (HDL-C),LDL-C, and triacylglycerols (TAG). Mean plasma levels of TC (B, 6.98+/-1.06 mM; IM, 7.09+/-1.20 mM), HDL-C(B,1.30+/-0.35 mM; IM, 1.29+/-0.34 mM), and LDL-C (B, 4.91+/-0.95 mM; IM, 4.92+/-1.10 mM) were not significantly differentbetween the two dietary treatments. Mean TAG levels were higher for the interesterified B-MCT mixture (B, 1.75+/-0.72 mM; IM,1.96+/-0.86 mM, P <0.05). We conclude that an IM of B, MCT, and safflower oils as compared to native B has no appreciable effect onplasma cholesterol concentrations but is associated with a modest rise in plasma TAG.
|Publication status||Published - 1999|