Abstract
Provided herein are composition including lipids and copolymers in the form of a nanodisc assembly. The copolymers include monomer units of methacrylic acid and styrene. Also provided herein is an aqueous solution comprising the subject composition, methods of producing the nanodisc assembly. Further provided are methods of solubilising hydrophobic constituents such as membrane proteins in aqueous solution, including forming nanodisc assemblies of a lipid, the hydrophobic constituent, and the subject copolymer.
| Original language | English |
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| IPC | G01N 33/ 68 A I |
| Patent number | WO2024153743 |
| Filing date | 18/01/2024 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Priority date | 18/01/2023 |
| Priority number | EP20230152204 |
| Publication status | Published - 25 Jul 2024 |