Lipid corralling and poloxamer squeeze-out in membranes

G.H. Wu, J. Majewski, C. Ege, K. Kjær, M. Weygand, K.Y.C. Lee

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Using x-ray scattering measurements we have quantitatively determined the effect of poloxamer 188 (P188), a polymer known to seal damaged membranes, on the structure of lipid monolayers. P188 selectively inserts into low lipid-density regions of the membrane and "corrals" lipid molecules to pack tightly, leading to unexpected Bragg peaks at low nominal lipid density and inducing lipid/poloxamer phase separation. At tighter lipid packing, the once inserted P188 is squeezed out, allowing the poloxamer to gracefully exit when the membrane integrity is restored.
    Original languageEnglish
    JournalPhysical Review Letters
    Volume93
    Issue number2
    Pages (from-to)028101
    Number of pages4
    ISSN0031-9007
    DOIs
    Publication statusPublished - 2004

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