Linking ontogeny and tissue regeneration: a study on tissue damage and wound healing in carp in connection to the developmental stage.

Michael Engelbrecht Nielsen, Jacob Schmidt, Hans-Christian Ingerslev

Research output: Contribution to conferencePosterResearch

Abstract

The immune system in vertebrates develops in sequential steps during the ontogeny. The very early immune response is characterised by a non-specific innate response, while later in development an adaptive memory-based response is acquired. Since the immune system has a significant role in wound healing and tissue regeneration, the developmental stage of the individual may influence the immune reaction initiated following damage and thus the proliferative responses, which usually cross-talk with the immune system. Common carp (Cyprinus carpio) is an excellent fish specie to study tissue regeneration since its genome is well-described and it is easy visually to follow the wound healing. In this study, carps were physically damaged in the musculature using sterile needles at day 10, 16, 24, 47 and 94 post hatch. Muscle tissue samples were subsequently taken at day 1, 3 and 7 post damage for further analysis by quantitative real-time PCR. The results are on-going, but gene-expression results on genes coding for the inflammatory response and proliferation / tissue regeneration from the different sampling points will be presented in order to examine the influences of the developmental stage.
Original languageEnglish
Publication date2011
Publication statusPublished - 2011
EventTissue Repair & Regeneration 2011
- Colby-Sawyer College, New London, United States
Duration: 5 Jun 201110 Jun 2011
Conference number: 10
https://www.grc.org/tissue-repair-and-regeneration-conference/2011/

Conference

ConferenceTissue Repair & Regeneration 2011
Number10
LocationColby-Sawyer College
CountryUnited States
CityNew London
Period05/06/201110/06/2011
OtherThe Gordon Research Conference (GRC) on Tissue Repair and Regeneration
Internet address

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