Limitations and possibilities of animal models for human allergenic risk evaluation

Charlotte Bernhard Madsen, Stine Kroghsbo, Katrine Lindholm Bøgh

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsResearchpeer-review

135 Downloads (Pure)

Abstract

There are many unanswered questions relating to food allergy sensitization in humans. We don’t know under what circumstances sensitization takes place i.e. route (oral, dermal, respiratory), age, dose, frequency of exposure, infection or by-stander effect of other allergens. In addition we don’t know under what circumstances oral tolerance develops.
With all these unanswered questions, it is a big challenge to design an animal model that, with relatively few animals, is able to predict if a food allergen is not only a potential allergen but also predict its potency, a prerequisite for risk evaluation.
One of the pitfalls may be the premise that an animal model needs to mimic the disease. Chemical contact sensitizers may be predicted in an animal test, the Local Lymph Node Assay (LLNA). This assay is based on detailed mechanistic knowledge of contact sensitization including knowledge on dose-response relationship. The outcome of the test is sensitization measured as cell proliferation in the regional lymph node.
Animal models in food allergy can be used to increase our understanding of food allergens and food allergy sensitization e.g. the influence of digestion or processing or to compare closely related allergens. Examples of this will be given.
Original languageEnglish
Title of host publicationThe 7th meeting of the Immunotoxicology and Chemical Allergy Speciality Section ITCASS
Number of pages1
Place of PublicationKgs. Lyngby
PublisherTechnical University of Denmark
Publication date2012
Pages11-11
Publication statusPublished - 2012
Event7th Meeting of the Immunotoxicology and Chemical Allergy Speciality Section - LO-skolen, Helsingør, Denmark
Duration: 30 Aug 201231 Aug 2012
Conference number: 7

Conference

Conference7th Meeting of the Immunotoxicology and Chemical Allergy Speciality Section
Number7
LocationLO-skolen
CountryDenmark
CityHelsingør
Period30/08/201231/08/2012

Fingerprint Dive into the research topics of 'Limitations and possibilities of animal models for human allergenic risk evaluation'. Together they form a unique fingerprint.

Cite this