Activities per year
With all these unanswered questions, it is a big challenge to design an animal model that, with relatively few animals, is able to predict if a food allergen is not only a potential allergen but also predict its potency, a prerequisite for risk evaluation.
One of the pitfalls may be the premise that an animal model needs to mimic the disease. Chemical contact sensitizers may be predicted in an animal test, the Local Lymph Node Assay (LLNA). This assay is based on detailed mechanistic knowledge of contact sensitization including knowledge on dose-response relationship. The outcome of the test is sensitization measured as cell proliferation in the regional lymph node.
Animal models in food allergy can be used to increase our understanding of food allergens and food allergy sensitization e.g. the influence of digestion or processing or to compare closely related allergens. Examples of this will be given.
|Title of host publication||The 7th meeting of the Immunotoxicology and Chemical Allergy Speciality Section ITCASS|
|Number of pages||1|
|Place of Publication||Kgs. Lyngby|
|Publisher||Technical University of Denmark|
|Publication status||Published - 2012|
|Event||7th Meeting of the Immunotoxicology and Chemical Allergy Speciality Section - LO-skolen, Helsingør, Denmark|
Duration: 30 Aug 2012 → 31 Aug 2012
Conference number: 7
|Conference||7th Meeting of the Immunotoxicology and Chemical Allergy Speciality Section|
|Period||30/08/2012 → 31/08/2012|
Charlotte Bernhard Madsen (Organizer)30 Aug 2012 → 31 Aug 2012
Activity: Attending an event › Participating in or organising a conferenceFile