Light Robotics – a growing toolbox for biomedical research

Ada-Ioana Bunea (Invited author), Jesper Glückstad (Invited author)

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    Abstract

    Research in the field of injectables spans a wide range of disciplines, from the chemical synthesis of novel drug candidates to the engineering of improved devices for subcutaneous, intradermal or intramuscular administration of biopharmaceuticals. For understanding and overcoming existing challenges in the field, an interdisciplinary approach relying on the latest research tools is needed. Light Robotics might prove a valuable toolbox for research in the field of injectables. By combining intelligent optical actuation with a high degree of control over the shape and surface properties of microfabricated structures, Light Robotics enables active investigation of biological samples and processes. As one of the pioneers in the field, our group develops microrobots for biomedical applications and advanced light sculpting techniques for their efficient optical manipulation. Two-photon polymerization enables direct laser writing of structures with a resolution of ~200 nm, which can be further improved to ~10 nm by post-processing or additional control over the printing process. In combination with surface modification via metal deposition or chemical functionalization, such microstructures can be tailored to specific applications for biomedical research purposes, such as material delivery or localized mixing in microfluidic channels. Light sculpting using methods from the Generalized Phase Contrast (GPC) family allows precise, simultaneous control of several microstructures with six degrees of freedom.
    Original languageEnglish
    Publication date2018
    Number of pages1
    Publication statusPublished - 2018
    EventCopenhagen Workshop on Injectables - Panum Institute, Copenhagen, Denmark
    Duration: 25 Oct 201825 Oct 2018

    Conference

    ConferenceCopenhagen Workshop on Injectables
    LocationPanum Institute
    Country/TerritoryDenmark
    CityCopenhagen
    Period25/10/201825/10/2018

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