Light-controlled out-of-equilibrium assembly of cyclodextrins in an enzyme-mediated dynamic system

Dennis Larsen; Philip M. Bjerre; Sophie R. Beeren

doi:10.1039/c9cc08452e

Light-controlled out-of-equilibrium assembly of cyclodextrins in an enzyme-mediated dynamic system

Dennis Larsen, Philip M. Bjerre, Sophie R. Beeren^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

18 Downloads (Pure)

Abstract

We show that the selective enzymatic synthesis of specific cyclodextrins can be modulated using light. We use enzyme-mediated dynamic combinatorial chemistry to generate a mixture of interconverting linear and cyclic α-1,4-glucans, and employ an azobenzene photoswitch as a template. Using UV or blue light to switch between photostationary states with different azobenzene cis/trans isomeric ratios, we can promote the out-of-equilibrium assembly of either α-cyclodextrin or β-cyclodextrin.

Original language	English
Journal	Chemical Communications
Volume	55
Issue number	100
Pages (from-to)	15037-15040
ISSN	1359-7345
DOIs	https://doi.org/10.1039/c9cc08452e
Publication status	Published - 2019

Access to Document

10.1039/c9cc08452e

FulltextAccepted author manuscript, 504 KB

Fingerprint Dive into the research topics of 'Light-controlled out-of-equilibrium assembly of cyclodextrins in an enzyme-mediated dynamic system'. Together they form a unique fingerprint.

Cite this

@article{fd03e47fa1894229bc699f2096c38eb2,

title = "Light-controlled out-of-equilibrium assembly of cyclodextrins in an enzyme-mediated dynamic system",

abstract = "We show that the selective enzymatic synthesis of specific cyclodextrins can be modulated using light. We use enzyme-mediated dynamic combinatorial chemistry to generate a mixture of interconverting linear and cyclic α-1,4-glucans, and employ an azobenzene photoswitch as a template. Using UV or blue light to switch between photostationary states with different azobenzene cis/trans isomeric ratios, we can promote the out-of-equilibrium assembly of either α-cyclodextrin or β-cyclodextrin.",

author = "Dennis Larsen and Bjerre, {Philip M.} and Beeren, {Sophie R.}",

year = "2019",

doi = "10.1039/c9cc08452e",

language = "English",

volume = "55",

pages = "15037--15040",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "100",

}

TY - JOUR

T1 - Light-controlled out-of-equilibrium assembly of cyclodextrins in an enzyme-mediated dynamic system

AU - Larsen, Dennis

AU - Bjerre, Philip M.

AU - Beeren, Sophie R.

PY - 2019

Y1 - 2019

N2 - We show that the selective enzymatic synthesis of specific cyclodextrins can be modulated using light. We use enzyme-mediated dynamic combinatorial chemistry to generate a mixture of interconverting linear and cyclic α-1,4-glucans, and employ an azobenzene photoswitch as a template. Using UV or blue light to switch between photostationary states with different azobenzene cis/trans isomeric ratios, we can promote the out-of-equilibrium assembly of either α-cyclodextrin or β-cyclodextrin.

AB - We show that the selective enzymatic synthesis of specific cyclodextrins can be modulated using light. We use enzyme-mediated dynamic combinatorial chemistry to generate a mixture of interconverting linear and cyclic α-1,4-glucans, and employ an azobenzene photoswitch as a template. Using UV or blue light to switch between photostationary states with different azobenzene cis/trans isomeric ratios, we can promote the out-of-equilibrium assembly of either α-cyclodextrin or β-cyclodextrin.

U2 - 10.1039/c9cc08452e

DO - 10.1039/c9cc08452e

M3 - Journal article

C2 - 31782430

VL - 55

SP - 15037

EP - 15040

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 100

ER -