Light-controlled out-of-equilibrium assembly of cyclodextrins in an enzyme-mediated dynamic system

Dennis Larsen, Philip M. Bjerre, Sophie R. Beeren*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We show that the selective enzymatic synthesis of specific cyclodextrins can be modulated using light. We use enzyme-mediated dynamic combinatorial chemistry to generate a mixture of interconverting linear and cyclic α-1,4-glucans, and employ an azobenzene photoswitch as a template. Using UV or blue light to switch between photostationary states with different azobenzene cis/trans isomeric ratios, we can promote the out-of-equilibrium assembly of either α-cyclodextrin or β-cyclodextrin.
Original languageEnglish
JournalChemical Communications
Volume55
Issue number100
Pages (from-to)15037-15040
Number of pages4
ISSN1359-7345
DOIs
Publication statusPublished - 2019

Cite this

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title = "Light-controlled out-of-equilibrium assembly of cyclodextrins in an enzyme-mediated dynamic system",
abstract = "We show that the selective enzymatic synthesis of specific cyclodextrins can be modulated using light. We use enzyme-mediated dynamic combinatorial chemistry to generate a mixture of interconverting linear and cyclic α-1,4-glucans, and employ an azobenzene photoswitch as a template. Using UV or blue light to switch between photostationary states with different azobenzene cis/trans isomeric ratios, we can promote the out-of-equilibrium assembly of either α-cyclodextrin or β-cyclodextrin.",
author = "Dennis Larsen and Bjerre, {Philip M.} and Beeren, {Sophie R.}",
year = "2019",
doi = "10.1039/c9cc08452e",
language = "English",
volume = "55",
pages = "15037--15040",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
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Light-controlled out-of-equilibrium assembly of cyclodextrins in an enzyme-mediated dynamic system. / Larsen, Dennis; Bjerre, Philip M.; Beeren, Sophie R.

In: Chemical Communications, Vol. 55, No. 100, 2019, p. 15037-15040.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Light-controlled out-of-equilibrium assembly of cyclodextrins in an enzyme-mediated dynamic system

AU - Larsen, Dennis

AU - Bjerre, Philip M.

AU - Beeren, Sophie R.

PY - 2019

Y1 - 2019

N2 - We show that the selective enzymatic synthesis of specific cyclodextrins can be modulated using light. We use enzyme-mediated dynamic combinatorial chemistry to generate a mixture of interconverting linear and cyclic α-1,4-glucans, and employ an azobenzene photoswitch as a template. Using UV or blue light to switch between photostationary states with different azobenzene cis/trans isomeric ratios, we can promote the out-of-equilibrium assembly of either α-cyclodextrin or β-cyclodextrin.

AB - We show that the selective enzymatic synthesis of specific cyclodextrins can be modulated using light. We use enzyme-mediated dynamic combinatorial chemistry to generate a mixture of interconverting linear and cyclic α-1,4-glucans, and employ an azobenzene photoswitch as a template. Using UV or blue light to switch between photostationary states with different azobenzene cis/trans isomeric ratios, we can promote the out-of-equilibrium assembly of either α-cyclodextrin or β-cyclodextrin.

U2 - 10.1039/c9cc08452e

DO - 10.1039/c9cc08452e

M3 - Journal article

C2 - 31782430

VL - 55

SP - 15037

EP - 15040

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 100

ER -