Light-controlled out-of-equilibrium assembly of cyclodextrins in an enzyme-mediated dynamic system

Dennis Larsen; Philip M. Bjerre; Sophie R. Beeren

doi:10.1039/c9cc08452e

Light-controlled out-of-equilibrium assembly of cyclodextrins in an enzyme-mediated dynamic system

Dennis Larsen, Philip M. Bjerre, Sophie R. Beeren^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

We show that the selective enzymatic synthesis of specific cyclodextrins can be modulated using light. We use enzyme-mediated dynamic combinatorial chemistry to generate a mixture of interconverting linear and cyclic α-1,4-glucans, and employ an azobenzene photoswitch as a template. Using UV or blue light to switch between photostationary states with different azobenzene cis/trans isomeric ratios, we can promote the out-of-equilibrium assembly of either α-cyclodextrin or β-cyclodextrin.

Original language	English
Journal	Chemical Communications
Volume	55
Issue number	100
Pages (from-to)	15037-15040
ISSN	1359-7345
DOIs	https://doi.org/10.1039/c9cc08452e
Publication status	Published - 2019

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title = "Light-controlled out-of-equilibrium assembly of cyclodextrins in an enzyme-mediated dynamic system",

abstract = "We show that the selective enzymatic synthesis of specific cyclodextrins can be modulated using light. We use enzyme-mediated dynamic combinatorial chemistry to generate a mixture of interconverting linear and cyclic α-1,4-glucans, and employ an azobenzene photoswitch as a template. Using UV or blue light to switch between photostationary states with different azobenzene cis/trans isomeric ratios, we can promote the out-of-equilibrium assembly of either α-cyclodextrin or β-cyclodextrin.",

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AB - We show that the selective enzymatic synthesis of specific cyclodextrins can be modulated using light. We use enzyme-mediated dynamic combinatorial chemistry to generate a mixture of interconverting linear and cyclic α-1,4-glucans, and employ an azobenzene photoswitch as a template. Using UV or blue light to switch between photostationary states with different azobenzene cis/trans isomeric ratios, we can promote the out-of-equilibrium assembly of either α-cyclodextrin or β-cyclodextrin.

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DO - 10.1039/c9cc08452e

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