Light-controlled out-of-equilibrium assembly of cyclodextrins in an enzyme-mediated dynamic system

Dennis Larsen, Philip M. Bjerre, Sophie R. Beeren*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

We show that the selective enzymatic synthesis of specific cyclodextrins can be modulated using light. We use enzyme-mediated dynamic combinatorial chemistry to generate a mixture of interconverting linear and cyclic α-1,4-glucans, and employ an azobenzene photoswitch as a template. Using UV or blue light to switch between photostationary states with different azobenzene cis/trans isomeric ratios, we can promote the out-of-equilibrium assembly of either α-cyclodextrin or β-cyclodextrin.
Original languageEnglish
JournalChemical Communications
Volume55
Issue number100
Pages (from-to)15037-15040
ISSN1359-7345
DOIs
Publication statusPublished - 2019

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