Leveraging European infrastructures to access 1 million human genomes by 2022

Gary Saunders, Michael Baudis, Regina Becker, Sergi Beltran, Christophe Béroud, Ewan Birney, Cath Brooksbank, Søren Brunak, Marc Van den Bulcke, Rachel Drysdale, Salvador Capella-Gutierrez, Paul Flicek, Francesco Florindi, Peter Goodhand, Ivo Gut, Jaap Heringa, Petr Holub, Jef Hooyberghs, Nick Juty, Thomas M. KeaneJan O. Korbel, Ilkka Lappalainen, Brane Leskosek, Gert Matthijs, Michaela Th. Mayrhofer, Andres Metspalu, Arcadi Navarro, Steven Newhouse, Tommi Nyrönen, Angela Page, Bengt Persson, Aarno Palotie, Helen Parkinson, Jordi Rambla, David Salgado, Erik Steinfelder, Morris A. Swertz, Alfonso Valencia, Susheel Varma, Niklas Blomberg, Serena Scollen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Human genomics is undergoing a step change from being a predominantly research-driven activity to one driven through health care as many countries in Europe now have nascent precision medicine programmes. To maximize the value of the genomic data generated, these data will need to be shared between institutions and across countries. In recognition of this challenge, 21 European countries recently signed a declaration to transnationally share data on at least 1 million human genomes by 2022. In this Roadmap, we identify the challenges of data sharing across borders and demonstrate that European research infrastructures are well-positioned to support the rapid implementation of widespread genomic data access.
Original languageEnglish
JournalNature Reviews. Genetics
Volume20
Pages (from-to)693-701
Number of pages9
ISSN1471-0056
DOIs
Publication statusPublished - 2019

Cite this

Saunders, G., Baudis, M., Becker, R., Beltran, S., Béroud, C., Birney, E., ... Scollen, S. (2019). Leveraging European infrastructures to access 1 million human genomes by 2022. Nature Reviews. Genetics, 20, 693-701. https://doi.org/10.1038/s41576-019-0156-9
Saunders, Gary ; Baudis, Michael ; Becker, Regina ; Beltran, Sergi ; Béroud, Christophe ; Birney, Ewan ; Brooksbank, Cath ; Brunak, Søren ; Van den Bulcke, Marc ; Drysdale, Rachel ; Capella-Gutierrez, Salvador ; Flicek, Paul ; Florindi, Francesco ; Goodhand, Peter ; Gut, Ivo ; Heringa, Jaap ; Holub, Petr ; Hooyberghs, Jef ; Juty, Nick ; Keane, Thomas M. ; Korbel, Jan O. ; Lappalainen, Ilkka ; Leskosek, Brane ; Matthijs, Gert ; Mayrhofer, Michaela Th. ; Metspalu, Andres ; Navarro, Arcadi ; Newhouse, Steven ; Nyrönen, Tommi ; Page, Angela ; Persson, Bengt ; Palotie, Aarno ; Parkinson, Helen ; Rambla, Jordi ; Salgado, David ; Steinfelder, Erik ; Swertz, Morris A. ; Valencia, Alfonso ; Varma, Susheel ; Blomberg, Niklas ; Scollen, Serena. / Leveraging European infrastructures to access 1 million human genomes by 2022. In: Nature Reviews. Genetics. 2019 ; Vol. 20. pp. 693-701.
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abstract = "Human genomics is undergoing a step change from being a predominantly research-driven activity to one driven through health care as many countries in Europe now have nascent precision medicine programmes. To maximize the value of the genomic data generated, these data will need to be shared between institutions and across countries. In recognition of this challenge, 21 European countries recently signed a declaration to transnationally share data on at least 1 million human genomes by 2022. In this Roadmap, we identify the challenges of data sharing across borders and demonstrate that European research infrastructures are well-positioned to support the rapid implementation of widespread genomic data access.",
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Saunders, G, Baudis, M, Becker, R, Beltran, S, Béroud, C, Birney, E, Brooksbank, C, Brunak, S, Van den Bulcke, M, Drysdale, R, Capella-Gutierrez, S, Flicek, P, Florindi, F, Goodhand, P, Gut, I, Heringa, J, Holub, P, Hooyberghs, J, Juty, N, Keane, TM, Korbel, JO, Lappalainen, I, Leskosek, B, Matthijs, G, Mayrhofer, MT, Metspalu, A, Navarro, A, Newhouse, S, Nyrönen, T, Page, A, Persson, B, Palotie, A, Parkinson, H, Rambla, J, Salgado, D, Steinfelder, E, Swertz, MA, Valencia, A, Varma, S, Blomberg, N & Scollen, S 2019, 'Leveraging European infrastructures to access 1 million human genomes by 2022', Nature Reviews. Genetics, vol. 20, pp. 693-701. https://doi.org/10.1038/s41576-019-0156-9

Leveraging European infrastructures to access 1 million human genomes by 2022. / Saunders, Gary; Baudis, Michael; Becker, Regina; Beltran, Sergi; Béroud, Christophe; Birney, Ewan; Brooksbank, Cath; Brunak, Søren; Van den Bulcke, Marc; Drysdale, Rachel; Capella-Gutierrez, Salvador; Flicek, Paul; Florindi, Francesco; Goodhand, Peter; Gut, Ivo; Heringa, Jaap; Holub, Petr; Hooyberghs, Jef; Juty, Nick; Keane, Thomas M.; Korbel, Jan O.; Lappalainen, Ilkka; Leskosek, Brane; Matthijs, Gert; Mayrhofer, Michaela Th.; Metspalu, Andres; Navarro, Arcadi; Newhouse, Steven; Nyrönen, Tommi; Page, Angela; Persson, Bengt; Palotie, Aarno; Parkinson, Helen; Rambla, Jordi; Salgado, David; Steinfelder, Erik; Swertz, Morris A.; Valencia, Alfonso; Varma, Susheel; Blomberg, Niklas; Scollen, Serena.

In: Nature Reviews. Genetics, Vol. 20, 2019, p. 693-701.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Leveraging European infrastructures to access 1 million human genomes by 2022

AU - Saunders, Gary

AU - Baudis, Michael

AU - Becker, Regina

AU - Beltran, Sergi

AU - Béroud, Christophe

AU - Birney, Ewan

AU - Brooksbank, Cath

AU - Brunak, Søren

AU - Van den Bulcke, Marc

AU - Drysdale, Rachel

AU - Capella-Gutierrez, Salvador

AU - Flicek, Paul

AU - Florindi, Francesco

AU - Goodhand, Peter

AU - Gut, Ivo

AU - Heringa, Jaap

AU - Holub, Petr

AU - Hooyberghs, Jef

AU - Juty, Nick

AU - Keane, Thomas M.

AU - Korbel, Jan O.

AU - Lappalainen, Ilkka

AU - Leskosek, Brane

AU - Matthijs, Gert

AU - Mayrhofer, Michaela Th.

AU - Metspalu, Andres

AU - Navarro, Arcadi

AU - Newhouse, Steven

AU - Nyrönen, Tommi

AU - Page, Angela

AU - Persson, Bengt

AU - Palotie, Aarno

AU - Parkinson, Helen

AU - Rambla, Jordi

AU - Salgado, David

AU - Steinfelder, Erik

AU - Swertz, Morris A.

AU - Valencia, Alfonso

AU - Varma, Susheel

AU - Blomberg, Niklas

AU - Scollen, Serena

PY - 2019

Y1 - 2019

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AB - Human genomics is undergoing a step change from being a predominantly research-driven activity to one driven through health care as many countries in Europe now have nascent precision medicine programmes. To maximize the value of the genomic data generated, these data will need to be shared between institutions and across countries. In recognition of this challenge, 21 European countries recently signed a declaration to transnationally share data on at least 1 million human genomes by 2022. In this Roadmap, we identify the challenges of data sharing across borders and demonstrate that European research infrastructures are well-positioned to support the rapid implementation of widespread genomic data access.

U2 - 10.1038/s41576-019-0156-9

DO - 10.1038/s41576-019-0156-9

M3 - Journal article

C2 - 31455890

VL - 20

SP - 693

EP - 701

JO - Nature Reviews. Genetics

JF - Nature Reviews. Genetics

SN - 1471-0056

ER -