Levels of Pesticides and Their Metabolites in Wistar Rat Amniotic Fluids and Maternal Urine upon Gestational Exposure.

Rossana Bossi, Anne Marie Vinggaard, Camilla Taxvig, Julie Boberg, Eva Cecilie Bonefeld-Jørgensen

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Abstract

Concentrations of pesticides and selected metabolites in rat urine and amniotic fluid were determined as biomarker upon oral administration of Wistar rats to two pesticide mixtures consisting of three to five pesticides (bitertanol, propiconazole, cypermethrin, malathion, and terbuthylazine). The pesticides and their metabolites were found in rat amniotic fluid and urine, generally in dose-response concentrations in relation to dosage. The measurement of the substances in the amniotic fluid indicated that the fetus was exposed to the pesticides as well as their metabolites. Moreover, the pesticides detected in urine demonstrated the exposure as well as the ability of the rat to excrete these compounds.
Original languageEnglish
JournalInternational Journal of Environmental Research and Public Health
Volume10
Issue number6
Pages (from-to)2271-2281
ISSN1661-7827
DOIs
Publication statusPublished - 2013

Keywords

  • Pesticides
  • Gestational exposure
  • In vivo experiment
  • Wistar rats

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