Leaky Opto-Electrical Neural Probe for Optical Stimulation and Electrochemical Detection of Dopamine Exocytosis

Shashank Vasudevan; Janko Kajtez; Arto Heiskanen; Jenny Emnéus; Stephan Sylvest Keller

doi:10.1109/mems46641.2020.9056270

Leaky Opto-Electrical Neural Probe for Optical Stimulation and Electrochemical Detection of Dopamine Exocytosis

Shashank Vasudevan, Janko Kajtez, Arto Heiskanen, Jenny Emnéus, Stephan Sylvest Keller^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Abstract

This paper reports on the fabrication and characterization of leaky opto-electrical neural probes for optical stimulation and real time electrochemical detection of dopamine exocytosis from optogenetically modified neural stem cells. Indentations were introduced in a SU-8 waveguide structure, patterned directly on the probe shank, to allow light to leak over a large area. Pyrolytic carbon electrodes fabricated on both sides of the leaky waveguide allow for real time detection of dopamine. The electrochemical characterization of the pyrolytic carbon demonstrates excellent conductivity and suitability for dopamine detection.

Original language	English
Title of host publication	Proceedings of the 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS)
Number of pages	4
Publisher	IEEE
Publication date	2020
Pages	388-391
Article number	9056270
ISBN (Electronic)	978-1-7281-3581-6
DOIs	https://doi.org/10.1109/mems46641.2020.9056270
Publication status	Published - 2020
Event	2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems - Vancouver, Canada Duration: 18 Jan 2020 → 20 Jan 2020

Conference

Conference	2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems
Country	Canada
City	Vancouver
Period	18/01/2020 → 20/01/2020

Series	International Conference on Micro Electro Mechanical Systems
ISSN	1084-6999

Keywords

Optical neural probe
Leaky waveguide
Optogenetics
Electrochemistry
Dopamine detection

Access to Document

10.1109/mems46641.2020.9056270

Cite this

Vasudevan, S., Kajtez, J., Heiskanen, A., Emnéus, J., & Keller, S. S. (2020). Leaky Opto-Electrical Neural Probe for Optical Stimulation and Electrochemical Detection of Dopamine Exocytosis. In Proceedings of the 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS) (pp. 388-391). [9056270] IEEE. International Conference on Micro Electro Mechanical Systems https://doi.org/10.1109/mems46641.2020.9056270

Vasudevan, Shashank ; Kajtez, Janko ; Heiskanen, Arto ; Emnéus, Jenny ; Keller, Stephan Sylvest. / Leaky Opto-Electrical Neural Probe for Optical Stimulation and Electrochemical Detection of Dopamine Exocytosis. Proceedings of the 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2020. pp. 388-391 (International Conference on Micro Electro Mechanical Systems).

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title = "Leaky Opto-Electrical Neural Probe for Optical Stimulation and Electrochemical Detection of Dopamine Exocytosis",

abstract = "This paper reports on the fabrication and characterization of leaky opto-electrical neural probes for optical stimulation and real time electrochemical detection of dopamine exocytosis from optogenetically modified neural stem cells. Indentations were introduced in a SU-8 waveguide structure, patterned directly on the probe shank, to allow light to leak over a large area. Pyrolytic carbon electrodes fabricated on both sides of the leaky waveguide allow for real time detection of dopamine. The electrochemical characterization of the pyrolytic carbon demonstrates excellent conductivity and suitability for dopamine detection.",

keywords = "Optical neural probe, Leaky waveguide, Optogenetics, Electrochemistry, Dopamine detection",

author = "Shashank Vasudevan and Janko Kajtez and Arto Heiskanen and Jenny Emn{\'e}us and Keller, {Stephan Sylvest}",

year = "2020",

doi = "10.1109/mems46641.2020.9056270",

language = "English",

series = "International Conference on Micro Electro Mechanical Systems",

publisher = "IEEE",

pages = "388--391",

booktitle = "Proceedings of the 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS)",

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note = "2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems, MEMS 2020 ; Conference date: 18-01-2020 Through 20-01-2020",

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Vasudevan, S, Kajtez, J , Heiskanen, A , Emnéus, J & Keller, SS 2020, Leaky Opto-Electrical Neural Probe for Optical Stimulation and Electrochemical Detection of Dopamine Exocytosis. in Proceedings of the 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS)., 9056270, IEEE, International Conference on Micro Electro Mechanical Systems, pp. 388-391, 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems, Vancouver, Canada, 18/01/2020. https://doi.org/10.1109/mems46641.2020.9056270

Leaky Opto-Electrical Neural Probe for Optical Stimulation and Electrochemical Detection of Dopamine Exocytosis. / Vasudevan, Shashank; Kajtez, Janko ; Heiskanen, Arto ; Emnéus, Jenny ; Keller, Stephan Sylvest.

Proceedings of the 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2020. p. 388-391 9056270 (International Conference on Micro Electro Mechanical Systems).

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

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AU - Emnéus, Jenny

AU - Keller, Stephan Sylvest

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AB - This paper reports on the fabrication and characterization of leaky opto-electrical neural probes for optical stimulation and real time electrochemical detection of dopamine exocytosis from optogenetically modified neural stem cells. Indentations were introduced in a SU-8 waveguide structure, patterned directly on the probe shank, to allow light to leak over a large area. Pyrolytic carbon electrodes fabricated on both sides of the leaky waveguide allow for real time detection of dopamine. The electrochemical characterization of the pyrolytic carbon demonstrates excellent conductivity and suitability for dopamine detection.

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KW - Optogenetics

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KW - Dopamine detection

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Vasudevan S, Kajtez J , Heiskanen A , Emnéus J , Keller SS. Leaky Opto-Electrical Neural Probe for Optical Stimulation and Electrochemical Detection of Dopamine Exocytosis. In Proceedings of the 2020 IEEE 33rd International Conference on Micro Electro Mechanical Systems (MEMS). IEEE. 2020. p. 388-391. 9056270. (International Conference on Micro Electro Mechanical Systems). https://doi.org/10.1109/mems46641.2020.9056270