LC-MS at core of university-industry link

Rune Linding

    Research output: Contribution to journalJournal articleResearchpeer-review


    LC-MS at core of university-industry link Thermo Fisher Scientific (TFS) and the Department of Systems Biology at the Technical University of Denmark, (DTU),
    have formed a collaboration to pursue breakthroughs in the understanding of how cellular protein networks drive important diseases by exploiting liquid chromatography coupled to mass spectrometry (LC-MS). TFS will provide early access to new technology and designs, and DTU proteomics scientists will rovide feedback and collaborate on new applications. The centerpiece of this collaboration is a new proteomics laboratory in Lyngby, Denmark, equipped with the latest LC-MS technology, including the TFS Orbitrap Fusion Tribrid LC-MS system that offers unprecedented depth of analysis of biological samples.
    ‘‘Studying the dynamic rewiring of cellular signaling networks requires state-ofthe-art mass spectrometry,’’ said DTU’s Professor Rune Linding (Fig. 8). ‘‘The Orbitrap Fusion system enables us to push the boundaries and to analyze completely new avenues of cellular decision processes, and to perform genome-scale studies of how the dynamics in these networks affect cell behavior.
    This is crucial, as it is now clear that the progression of complex diseases, such as cancer, is due to changes in these molecular networks. ‘‘We were extremely excited to see, only a few days after installation, the Orbitrap Fusion system generate the best MS/MS data we have ever seen for the characterization of phosphorylation sites on critical tumor samples.’’ ‘‘We are immensely pleased to be working with this talented and motivated team of scientists,’’ said Iain Mylchreest, vice president, research and development, life science mass spectrometry, TFS. ‘‘We share with them the objective of pushing the limits of science to make the world a better place, and the Orbitrap Fusion Tribrid system is designed for precisely this type of visionary research.’’ DTU is establishing the state-of-the-art laboratory to develop new experiments to dig deeper into the core machinery of the cell. The new laboratory will use four TFS Q
    Exactive LC-MS/MS systems, and nano-LC 1000 systems along with one of the first TFS Orbitrap Fusion Tribrid systems to leave the factory since its June 2013 debut.
    Original languageEnglish
    JournalTrends in Analytical Chemistry
    Pages (from-to)VIII-IX
    Publication statusPublished - 2013



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