Large-scale Virtual Clinical Trials of Closed-loop Treatments for People
  with Type 1 Diabetes

Tobias K. S. Ritschel; Asbjørn Thode Reenberg; John Bagterp Jørgensen

doi:10.1016/j.ifacol.2023.01.037

Large-scale Virtual Clinical Trials of Closed-loop Treatments for People with Type 1 Diabetes

Tobias K. S. Ritschel, Asbjørn Thode Reenberg, John Bagterp Jørgensen^*

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › Research › peer-review

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Abstract

We propose a virtual clinical trial for assessing the safety and efficacy of closed-loop diabetes treatments prior to an actual clinical trial. Such virtual trials enable rapid and risk-free pretrial testing of algorithms, and they can be used to compare different treatment variations for large and diverse populations. The participants are represented by multiple mathematical models, consisting of stochastic differential equations, and we use Monte Carlo closed-loop simulations to compute detailed statistics of the closed-loop treatments. We implement the virtual clinical trial using high-performance software and hardware, and we present an example trial with two mathematical models of one million participants over 52 weeks (i.e., two million simulations), which can be completed in 2 h 9 min.

Original language	English
Book series	IFAC-PapersOnLine
Volume	55
Issue number	23
Pages (from-to)	169-174
ISSN	2405-8963
DOIs	https://doi.org/10.1016/j.ifacol.2023.01.037
Publication status	Published - 2022
Event	9th IFAC Conference on Foundations of Systems Biology in Engineering : FOSBE 2022 - Cambridge, United States Duration: 28 Aug 2022 → 31 Aug 2022

Conference

Conference	9th IFAC Conference on Foundations of Systems Biology in Engineering
Country/Territory	United States
City	Cambridge
Period	28/08/2022 → 31/08/2022

Keywords

Virtual clinical trials
Diabetes
Stochastic modeling
High-performance computing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ifacol.2023.01.037Licence: CC BY-NC-ND

FulltextFinal published version, 707 KBLicence: CC BY-NC-ND

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Cite this

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