Large dose hyperpolarized water with dissolution-DNP at high magnetic field

Research output: Contribution to journalJournal article – Annual report year: 2016Researchpeer-review

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Large dose hyperpolarized water with dissolution-DNP at high magnetic field. / Lipsø, Hans Kasper Wigh; Bowen, Sean; Rybalko, Oleksandr; Ardenkjær-Larsen, Jan Henrik.

In: Journal of Magnetic Resonance, Vol. 274, 2016, p. 65-72.

Research output: Contribution to journalJournal article – Annual report year: 2016Researchpeer-review

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@article{d25395e4c329463b86496a7e8c1e90f6,
title = "Large dose hyperpolarized water with dissolution-DNP at high magnetic field",
abstract = "We demonstrate a method for the preparation of hyperpolarized water by dissolution Dynamic Nuclear Polarization at high magnetic field. Protons were polarized at 6.7T and 1.1K to >70{\%} with frequency modulated microwave irradiation at 188GHz. 97.2±0.7{\%} of the radical was extracted from the sample in the dissolution in a two-phase system. 16±1mL of 5.0M (1)H in D2O with a polarization of 13.0±0.9{\%} in the liquid state was obtained, corresponding to an enhancement factor of 4000±300 compared to the thermal equilibrium at 9.4T and 293K. A longitudinal relaxation time constant of 16±1s was measured. The sample was polarized and dissolved in a fluid path compatible with clinical polarizers. The volume of hyperpolarized water produced by this method enables angiography and perfusion measurements in large animals, as well as NMR experiments for studies of e.g. proton exchange and polarization transfer to other nuclei.",
keywords = "Dissolution-DNP, Hyperpolarization, Hyperpolarized water",
author = "Lips{\o}, {Hans Kasper Wigh} and Sean Bowen and Oleksandr Rybalko and Ardenkj{\ae}r-Larsen, {Jan Henrik}",
year = "2016",
doi = "10.1016/j.jmr.2016.11.008",
language = "English",
volume = "274",
pages = "65--72",
journal = "Journal of Magnetic Resonance",
issn = "1090-7807",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Large dose hyperpolarized water with dissolution-DNP at high magnetic field

AU - Lipsø, Hans Kasper Wigh

AU - Bowen, Sean

AU - Rybalko, Oleksandr

AU - Ardenkjær-Larsen, Jan Henrik

PY - 2016

Y1 - 2016

N2 - We demonstrate a method for the preparation of hyperpolarized water by dissolution Dynamic Nuclear Polarization at high magnetic field. Protons were polarized at 6.7T and 1.1K to >70% with frequency modulated microwave irradiation at 188GHz. 97.2±0.7% of the radical was extracted from the sample in the dissolution in a two-phase system. 16±1mL of 5.0M (1)H in D2O with a polarization of 13.0±0.9% in the liquid state was obtained, corresponding to an enhancement factor of 4000±300 compared to the thermal equilibrium at 9.4T and 293K. A longitudinal relaxation time constant of 16±1s was measured. The sample was polarized and dissolved in a fluid path compatible with clinical polarizers. The volume of hyperpolarized water produced by this method enables angiography and perfusion measurements in large animals, as well as NMR experiments for studies of e.g. proton exchange and polarization transfer to other nuclei.

AB - We demonstrate a method for the preparation of hyperpolarized water by dissolution Dynamic Nuclear Polarization at high magnetic field. Protons were polarized at 6.7T and 1.1K to >70% with frequency modulated microwave irradiation at 188GHz. 97.2±0.7% of the radical was extracted from the sample in the dissolution in a two-phase system. 16±1mL of 5.0M (1)H in D2O with a polarization of 13.0±0.9% in the liquid state was obtained, corresponding to an enhancement factor of 4000±300 compared to the thermal equilibrium at 9.4T and 293K. A longitudinal relaxation time constant of 16±1s was measured. The sample was polarized and dissolved in a fluid path compatible with clinical polarizers. The volume of hyperpolarized water produced by this method enables angiography and perfusion measurements in large animals, as well as NMR experiments for studies of e.g. proton exchange and polarization transfer to other nuclei.

KW - Dissolution-DNP

KW - Hyperpolarization

KW - Hyperpolarized water

U2 - 10.1016/j.jmr.2016.11.008

DO - 10.1016/j.jmr.2016.11.008

M3 - Journal article

VL - 274

SP - 65

EP - 72

JO - Journal of Magnetic Resonance

JF - Journal of Magnetic Resonance

SN - 1090-7807

ER -