Lactam hydrolysis catalyzed by mononuclear metallo-beta-lactamases: A density functional study

Engineering & Materials Science

• beta-Lactamases 100%
• Lactams 97%
• Proton transfer 94%
• Hydrolysis 62%
• Zinc 55%
• Ions 37%
• Protons 37%
• Metal ions 29%
• Antibiotics 29%
• Binding sites 28%
• Cadmium 14%
• Catalysis 13%
• Metals 13%
• Water 11%
• Atoms 10%
• Molecules 10%
• Nitrogen 9%

Chemical Compounds

• Lactam 56%
• Proton Transfer 46%
• Lactam Ring 46%
• Density Functional Theory 32%
• Hydrolysis 32%
• Zinc Ion 22%
• Proton 20%
• Beta Lactam Antibiotic Agent 19%
• Hydroxide 16%
• Glutamine Residue 15%
• Asparagine Residue 14%
• Beta-Lactam Antibiotic 13%
• Metal Ion 13%
• Histidine 9%
• Imidazole 8%
• Nitrogen Atom 8%
• Ion 8%
• Binding Site 7%
• Cleavage 7%
• Catalysis 6%

Physics & Astronomy

• hydrolysis 59%
• protons 33%
• zinc 28%
• antibiotics 17%
• rings 17%
• hydroxides 14%
• metal ions 13%
• ions 12%
• glutamine 10%
• breakdown 9%
• imidazoles 9%
• histidine 9%
• nitrogen atoms 7%
• catalysis 7%
• water 7%
• attack 6%
• cadmium 6%
• cleavage 6%
• metals 6%
• ligands 6%